Evidence map›Paper›PMID 39574147›Full record

ArticleMicrobial cell factories2024

Metformin regulates cellulase production in Trichoderma reesei via calcium signaling and mitochondrial function.

Jiajia Wang, Yumeng Chen, Jiawei Cong, Wei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. ROS-CaArchives of microbiology · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiajia Wang *The State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China.
Yumeng Chen *The State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China.
Jiawei CongThe State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China.
Wei WangThe State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China. wadexp@ecust.edu.cn.

Funding

Chenguang Program of the Shanghai Education Development Foundation, and Shanghai Municipal Education Commission 21CGA34National Key Research and Development Program of China 2022YFA0912300National Natural Science Foundation of China 32370093Natural Science Foundation of Shanghai Municipality 22ZR1417600 and 23ZR1414800
6 · The paper itself

Abstract

backgroundTrichoderma reesei is renowned for its cellulase-producing ability and is used for biofuel production from lignocellulose. In plants and fungi, cellulase production is induced by cellulose and suppressed by glucose; however, whether metformin can enhance cellulase production and mitochondrial function in T. reesei remains unclear. Metformin reduces blood glucose levels by inhibiting hepatic gluconeogenesis; therefore, it is worth investigating whether metformin transmission modulates cellulase biosynthesis in T. reesei.

resultsMetformin increased cellulase production and the transcription of cellulase-related genes. It also enhanced the concentrations of Ca

conclusionCollectively, these results indicate that metformin enhances cellulase production, scavenges ROS, and protects mitochondrial activity in T. reesei.

Indexed as

Calcium SignalingCellulaseMetforminMitochondriaReactive Oxygen SpeciesCalciumGene Expression Regulation, FungalHypocrealesCalciumCellulaseMetforminReactive Oxygen SpeciesCalcium signalingCellulaseMetforminMitochondriaROSTrichoderma reesei

Identifiers

PMID39574147
PMCPMC11580550

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.