Evidence map›Paper›PMID 39574569›Full record

ArticlebioRxiv : the preprint server for biology2025

TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes.

Christopher N Rudzitis, Monika Lakk, Ayushi Singh, Sarah N Redmon, Denisa Kirdajova, Yun-Ting Tseng, Michael L De Ieso, W Daniel Stamer, Samuel Herberg, David Križaj

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christopher N RudzitisDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.
Monika LakkDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.
Ayushi SinghDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY.
Sarah N RedmonDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.
Denisa KirdajovaDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.
Yun-Ting TsengDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.
Michael L De IesoDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC.
W Daniel StamerDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC.
Samuel HerbergDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY.ORCID 0000-0001-7196-2010
David KrižajDepartment of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT.ORCID 0000-0003-4468-3029

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
eNOS-Dependent Mechanoregulation of Intraocular PressureR01EY022359 · NEI · DUKE UNIVERSITY · PI STAMER, W DANIEL · 2012 to 2025
$5.6M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
Role of cellular memory in glaucoma.R01EY034096 · NEI · UPSTATE MEDICAL UNIVERSITY · PI Samuel Herberg · 2022 to 2026
$2.0M
The role of mechanosensation in the vertebrate retinaR01EY022076 · NEI · UNIVERSITY OF UTAH · PI KRIZAJ, DAVID · 2013 to 2017
$1.9M
TM/SC-interface-on-a-chip for mechanistic studies of outflow regulation.R21EY036189 · NEI · UPSTATE MEDICAL UNIVERSITY · PI HERBERG, SAMUEL · 2024 to 2025
$439k
NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY022076NEI NIH HHS R01 EY022359NEI NIH HHS R01 EY034096NEI NIH HHS R21 EY036189NEI NIH HHS T32 EY024234
6 · The paper itself

Abstract

The risk for developing primary open-angle glaucoma (POAG) correlates with the magnitude of ocular hypertension (OHT) and the concentration of transforming growth factor-β2 (TGFβ2) in the aqueous humor. Effective treatment of POAG requires detailed understanding of interaction between pressure sensing mechanisms in the trabecular meshwork (TM) and biochemical risk factors. Here, we employed molecular, optical, electrophysiological and tonometric strategies to establish the role of TGFβ2 in transcription and functional expression of mechanosensitive channel isoforms alongside studies of TM contractility in biomimetic hydrogels, and intraocular pressure (IOP) regulation in a mouse model of TGFβ2 -induced OHT. TGFβ2 upregulated expression of

Identifiers

PMID39574569
PMCPMC11580928

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.