ArticleArchives of internal medicine research2024
Etiology, Pathophysiology, and Treatment Strategies in the Prevention and Management of Metabolic Syndrome.
Article in Archives of internal medicine research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Community-Based Non-Pharmacological Intervention for Metabolic Syndrome in Chile: A Comparative Reanalysis of an Integrated Exercise and Health Education Program.International journal of environmental research and public health · 2026Trial
- Trial
- Natural Ellagitannins as Potential Therapeutic Agents for Metabolic Syndrome-Related Disorders.Foods (Basel, Switzerland) · 2026Review
- Biochemical Evaluation of Green-Synthesized Silver Nanoparticles Derived from Waste Eriobotrya Japonica Seeds: Enzyme Inhibition and Antiglycation Potential.Applied biochemistry and biotechnology · 2026Article
- Galectin-3, transforming growth factor beta 1, and brain natriuretic peptide in cardiac remodeling under hyperlipidemic and hyperglycemic stress.Molecular and cellular biochemistry · 2026Article
- Cardiometabolic Effects of Traditional South Asian Diets and the Growing Burden of Metabolic Syndrome.Archives of internal medicine research · 2026Article
- Association between the cardiometabolic index and intrinsic capacity and its domains in older adults: a study based on CHARLS data.BMC geriatrics · 2026Article
- Cardiorenal Protective Effects of Finerenone in Patients with Type 2 Diabetes Mellitus.Archives of internal medicine research · 2026Article
- Outcomes of Diabetes Management with Continuous Glucose Monitoring Technology.Archives of internal medicine research · 2026Article
- Prevalence and risk profiles of metabolic abnormalities (PRIMA): a large-scale, multicenter cross-sectional study among inpatients with schizophrenia in China.BMC psychiatry · 2026Article
- Utility of the US Metabolic Syndrome Severity Calculator for Group-Level Comparison in Estonia.Medicina (Kaunas, Lithuania) · 2026Article
- Demystifying the role of postbiotics in inflammation mediated metabolic disorders: an updated review.Food science and biotechnology · 2026Review
- Intricate interplay between ORMDL3, ER stress, and autophagy in the diabetic intestine.Molecular and cellular biochemistry · 2026Article
- Diallyl trisulfide attenuates metabolic syndromeFrontiers in pharmacology · 2026Article
- Cost-efficient and Accurate Risk Assessment Instruments in Type 2 Diabetics with Greatest Risk for Cardiovascular Disease.Cardiology and cardiovascular medicine · 2026Article
- Article
- Association Between Insulin Regimen and Cardiovascular Risk in Indonesian Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Therapeutics and clinical risk management · 2026Article
- Impact of a Lifestyle Intervention on Gut Microbiome Composition: A Quasi-Controlled Before-and-After Analysis.Metabolites · 2025Article
- Total bilirubin modifies the relationship between obesity and stroke.Diabetology & metabolic syndrome · 2025Article
- Metabolic Syndrome in Older Adults: Through the Lens of Institute for Healthcare Improvement's (IHI) 4Ms Framework and Social Determinants of Health.Life (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Metabolic Syndrome (MetS) is a complex cluster of metabolic irregularities that significantly increase the risk of developing chronic conditions, such as hypertension, type 2 diabetes, cardiovascular diseases, and other related disorders. This review aims to provide a comprehensive overview of the current understanding of MetS, its etiology and underlying pathogenesis, and the management strategies. MetS is characterized by central obesity, high blood pressure, insulin resistance, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein cholesterol levels. The prevalence of MetS is remarkably high, affecting approximately 25% of the global population, particularly in developed nations with inactive lifestyles and high-calorie diets. The development of MetS involves genetic and acquired factors, resulting in an inflammatory state that enhances the risk for cardiovascular disease. The biochemical alterations observed in MetS establish pathological connections between MetS, diabetes, and cardiovascular and neurodegenerative conditions. Despite its clinical importance, there is still debate regarding the precise components and pathophysiological associations among MetS elements. However, advancements in therapeutic measures, including drug therapies, surgical options, and experimental methods present promising avenues for managing and potentially reversing MetS. Further investigation of the MetS is critical because of its significant implications for public health and its connection to other clinical conditions and severe health outcomes, placing a substantial burden on healthcare system and society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.