ArticleFrontiers in endocrinology2024
Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits.International journal of molecular sciences · 2025Review
- Relationship between plasma atherogenic index and thyroid function: evidence from NHANES 2007-2012.Scientific reports · 2025Article
- A Preliminary Analysis of the Influence of Elderberry Juice Consumption on Thyroid Metabolism in Mice and Humans Fed High-Fat Diets.Nutrients · 2025Article
- Association between oxidative balance score and prevalence rates of thyroid dysfunction and autoimmune thyroiditis among U.S. adults: evidence from epidemiological studies.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although some evidence suggests a role for vitamin C intake in thyroid diseases, the complex interplay between vitamin C intake and thyroid function remains incompletely understood. The objective of this study was to explore the relationship between vitamin C intake and serum thyroid function in the United States adults. Methods: A total of 5,878 participants from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012 were included in this study. Weighted multivariate linear regression models, subgroup analyses, and interaction terms were used to assess the association between vitamin C intake, evaluated as a continuous and categorical variable, and thyroid function. Additionally, restricted cubic spline (RCS) regression was employed to assess any nonlinear relationship that may exist between vitamin C intake and thyroid function. Results: After adjusting for covariates, our research found a significant inverse correlation between vitamin C intake and total thyroxine (TT4) (β= -0.182, Conclusion: The findings of our study have illustrated a notable correlation between vitamin C intake and thyroid function. A high level of vitamin C intake is associated with a decreased in TT4 levels among American adults, and the association was more pronounced among subjects with lower alcohol consumption. Furthermore, our analysis revealed a nonlinear correlation between the intake of vitamin C and the levels of TT4, FT4, and FT3/FT4 ratio. Our findings support the rationale for making food-based dietary recommendations and maybe provide guidance for diet guidelines with thyroid dysfunction to a certain extent in the future.
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