ArticleCureus2024
Clinical Significance of miR-4535 and miR-191-5p in Maternal Serum as Independent Biomarkers for Severe Chorioamnionitis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- miR-191-5p attenuates TNF-α-induced inflammation in nucleus pulposus cells via targeting EGR1.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChorioamnionitis, a perinatal condition caused by fetal membrane inflammation, results in preterm birth, neonatal sepsis, necrotizing enterocolitis, and brain disease in infants. However, predicting maternal and fetal prognoses is challenging. We aimed to assess the relationship between fetal infection induced by severe chorioamnionitis or morbidity and the expression levels of serum miR-4535, miR-1915-5p, and miR-191-5p levels, which are promising biomarkers for chorioamnionitis, in pregnant women with chorioamnionitis.
methodsWe collectedserum and amniotic fluid samples from 40 pregnant women with preterm labor and analyzed miR-4535, miR-1915-5p, and miR-191-5p expressions. We calculated the area under the curve (AUC) and Youden index to examine the diagnostic accuracy of infection-induced fetal morbidity.
resultsThe serum miR-4535 and miR-191-5p levels were significantly higher in patients with severe chorioamnionitis than in those with chorionitis or sub-chorionitis (
conclusionSerum miR-4535 and miR-191-5p are associated with infection-induced severe chorioamnionitis and fetal morbidity and maternal infection, respectively.
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Registered trials
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