Evidence map›Paper›PMID 39576466›Full record

ArticleMolecular and cellular biochemistry2025

Unleashing the therapeutic power of verteporfin-eluting stents: modulating YAP signaling to combat carotid artery restenosis and cerebral watershed infarction.

Peng Zhang, Chenyang Xu, Zhijun Liu, Yadong Geng, Honglin Liu

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In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng ZhangDepartment of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
Chenyang XuDepartment of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
Zhijun LiuDepartment of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
Yadong GengDepartment of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
Honglin LiuDepartment of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China. 369879164@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid artery stenosis is the main cause of cerebral watershed infarction (CWI). In recent years, increasing attention has been given to treating this condition. The present study aimed to investigate how Verteporfin-eluting stent (VPES) modulates the YAP signaling pathway to inhibit restenosis of the carotid artery and alleviate CWI. Through transcriptome sequencing and functional experiments, it was found that VP could regulate the Yes-associated protein (YAP) signaling pathway and effectively suppress the proliferation and migration of smooth muscle cells (SMCs). Further investigation revealed that VPES could inhibit carotid artery restenosis through the YAP signaling pathway in a rabbit model, reducing the occurrence of CWI.

Indexed as

Adaptor Proteins, Signal TransducingCarotid StenosisCerebral InfarctionDrug-Eluting StentsSignal TransductionVerteporfinAnimalsHumansMaleMyocytes, Smooth MuscleRabbitsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingVerteporfinYAP-Signaling ProteinsCarotid artery restenosisCerebral watershed infarctionSmooth muscle cellsTranscriptome sequencingVerteporfin-eluting stentYAP signaling pathway

Identifiers

PMID39576466

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.