Observational studyGynecologic oncology2025
Association of neighborhood social vulnerability with ovarian cancer survival.
Observational study in Gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Differential effects of social determinants on cancer survival by age at diagnosis: A population-based study in Alabama.Journal of geriatric oncology · 2026Article
- Residential Context and Survival Disparities in Black and White Women With Ovarian Cancer.JAMA network open · 2026Observational
- Impact of patient neighborhood area deprivation index on prognostic factors and outcomes in endometrioid adenocarcinoma of the endometrium: a retrospective multi-center healthcare network analysis.Gynecologic oncology reports · 2026Article
- Impact of Marginalization Dimensions on Survival Disparities in Epithelial Ovarian Cancer: An Ontario Population-Based Study.Cancers · 2026Article
- Urban-rural residence location and cancer-specific mortality among colorectal, lung and ovarian cancer patients: a nationwide retrospective cohort study from Lithuania.Acta oncologica (Stockholm, Sweden) · 2025Article
- Community-level Social Vulnerability and Cervical Cancer Mortality Among Young and Old Adults in the State of Alabama.Journal of community health · 2025Article
- Association of social vulnerability with access to treatment in ovarian cancer patients.Gynecologic oncology reports · 2025Article
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Authors and funding
22 authors.
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Abstract
objectiveSocial determinants of health (SDOH) impact cancer outcomes. The CDC Social Vulnerability Index (SVI) integrates scores for four neighborhood-based SDOH domains (socioeconomic status, household characteristics, minority status, and housing type/transportation) to assess neighborhood social vulnerability (NSV). While NSV has been associated with overall cancer mortality and lung, breast, colon, and endometrial cancer-specific mortality, the relationship between NSV as defined by the SVI and ovarian cancer outcomes remains unknown.
methodsWe used data from 177 patients enrolled in an observational ovarian cancer cohort study from October 2012 through September 2022. All patients underwent debulking surgery and completed an entire course of standard-of-care platinum-based chemotherapy. Follow-up was completed through May 2024. SVI was calculated using census tract at diagnosis. High NSV was defined as SVI in the top quartile of the cohort. Cox proportional hazard models assessed the association between NSV and progression-free (PFS) and overall (OS) survival.
resultsAfter accounting for demographic and clinical factors, high NSV was associated with significantly worse PFS (HR:2.31 [95% CI:1.48-3.61]; P < 0.001) and OS (HR:1.79 [95% CI:1.10-2.92]; P = 0.02), with neighborhood socioeconomic status associated with significantly worse PFS (HR:2.29 [95% CI:1.47-3.56]; P < 0.001) and OS (HR:1.71 [95% CI:1.04-2.80]; P = 0.03). Neighborhood housing type/transportation was also associated with significantly worse PFS (HR:1.65 [95% CI:1.07-2.55]; P = 0.02) and trended towards worse OS (HR:1.43 [95% CI: 0.80-2.33]). CONCLUSION AND RELEVANCE: Higher neighborhood social vulnerability is associated with worse outcomes among ovarian cancer patients. Validating these results in a population-based cohort and assessing programs to reduce neighborhood social vulnerability to improve ovarian cancer outcomes is warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.