Evidence map›Paper›PMID 39578778›Full record

Observational studyBMC musculoskeletal disorders2024

Associations between hand osteoarthritis, obesity and lipid metabolism: a cross-sectional study of the Halland County Osteoarthritis (HALLOA) cohort.

Elisabeth Brogren, Maria Andersson, Melker Westenius, Jenny Wittrup, Malin Zimmerman

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04928170 (The Halland Osteoarthritis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04928170 active not recruitingnot on this map

The Halland Osteoarthritis (HALLOA) Cohort Study - a Five-year Observational Longitudinal Study With Focus on Metabolic Osteoarthritis

TypeobservationalSponsorFoU Center SpenshultRan2016 to 2024Enrolled312ConditionsOsteoarthritis, Knee, Osteoarthritis Hand, Osteoarthritis Generalized
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elisabeth BrogrenDepartment of Hand Surgery, Skåne University Hospital, Malmö, Sweden. elisabeth.brogren@med.lu.se.
Maria AnderssonDepartment of Clinical Sciences, Rheumatology, Lund University, Lund, Sweden.
Melker WesteniusDepartment of Translational Medicine, Lund University, Lund, Sweden.
Jenny WittrupBokskogen Primary Health Care Centre, Malmö, Sweden.
Malin ZimmermanDepartment of Translational Medicine, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort.

methodsIn this cross-sectional study, we included 231 participants aged 30-65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2-4 joint groups, severe hand OA 5-6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were obtained. Multicollinearity was assessed with Pearson's correlation and associations with logistic regression analyses adjusting for age, HDL-cholesterol, and central obesity.

resultsTwo-thirds of the participants were women, and 91 (39%) had hand OA. We found a relationship between LDL-cholesterol and prevalent hand OA in women with an odds ratio of 1.7 (95% CI 1.1-2.6) and an association between LDL-cholesterol and severity of hand OA in women; odds ratio for no hand OA vs. moderate hand OA was 1.6 (95% CI 1.0-2.4) and for no hand OA vs. severe hand OA 2.5 (95% CI 1.2-4.9). There were no significant relationships between hand OA and obesity or serum leptin levels.

conclusionCirculating LDL-cholesterol levels were associated with the prevalence and severity of hand OA in women but not men.

trial registrationClinicalTrials. Gov (NCT04928170), Date of registration: 2017-12-20.

Indexed as

Lipid MetabolismObesityOsteoarthritisAdultAgedBody Mass IndexCholesterol, LDLCohort StudiesCross-Sectional StudiesFemaleHand JointsHumansLeptinMaleMiddle AgedPrevalenceCholesterol, LDLLeptinBody mass indexCholesterol, HDLCholesterol, LDLLipid metabolismObestity, AbdominalOsteoarthritis

Identifiers

PMID39578778
PMCPMC11583440

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.