Evidence map›Paper›PMID 39579046›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Homonymous hemi-macular atrophy in multiple sclerosis.

Grigorios Kalaitzidis, Omar Ezzedin, Anna Bacchetti, Hussein Moussa, Olwen C Murphy, Angeliki G Filippatou, Henrik Ehrhardt, Eleni Vasileiou, Nicole Pellegrini, Simidele Davis and 10 more

Abstract read
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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Grigorios KalaitzidisDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-7680-3609
Omar EzzedinDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Anna BacchettiDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Hussein MoussaDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Olwen C MurphyDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-7880-8948
Angeliki G FilippatouDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0419-233X
Henrik EhrhardtDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Eleni VasileiouDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Nicole PellegriniDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Simidele DavisDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Morgan DouglasDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Kathryn C FitzgeraldDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-3137-0322
Anna DuValDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Scott Douglas NewsomeDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Elias S SotirchosDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8812-1637
Bardia NourbakhshDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-6617-2003
Blake E DeweyDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4554-5058
Jerry PrinceDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
Shiv SaidhaDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6387-0714
Peter A CalabresiDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7776-6472

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
NEI NIH HHS R01 EY032284NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

backgroundRetrograde trans-synaptic degeneration (TSD) following retro-chiasmal pathology, typically retro-geniculate in multiple sclerosis (MS), may manifest as homonymous hemi-macular atrophy (HHMA) of the ganglion cell/inner plexiform layer (GCIPL).

objectiveTo determine the frequency, association with clinical outcomes, and retinal and radiological features of HHMA in people with MS (PwMS).

methodsIn this cross-sectional study, healthy controls (HC) and PwMS underwent retinal optical coherence tomography scanning. For quantitative identification of HHMA, a normalized asymmetry ratio was used, and its normative cutoffs were established from the HC. HHMA PwMS were propensity score matched 1:2 to non-HHMA PwMS. Mixed-effects linear regression models were used in analyses.

resultsBased on normative data from 238 HC (466 eyes), 79 out of 942 PwMS exhibited HHMA (8.4%; 143 eyes). Compared to non-HHMA eyes from matched PwMS (158 PwMS; 308 eyes), HHMA eyes had lower average GCIPL (diff: -5.7 μm (95% CI -7.6 to -3.8);

conclusionsHHMA, possibly as a marker of TSD, may signify higher disability in MS.

Indexed as

AtrophyMultiple SclerosisTomography, Optical CoherenceAdultCross-Sectional StudiesFemaleHumansMacula LuteaMaleMiddle AgedRetinal Ganglion CellsRetrograde Degenerationganglion cell/inner plexiform layerhomonymous hemi-macular atrophymicrocystoid macular pathologymultiple sclerosisneurodegenerationoptical coherence tomographyTrans-synaptic degeneration

Identifiers

PMID39579046
PMCPMC11617262

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.