Evidence map›Paper›PMID 39579048›Full record

ReviewMicrobial biotechnology2024

Living Engineered Bacterial Therapeutics: Emerging Affordable Precision Interventions.

Rajkamal Srivastava, Cammie F Lesser

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  7. Beneficial perspective onFrontiers in immunology · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rajkamal SrivastavaCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0009-0004-9167-9721
Cammie F LesserCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1702-6333

Funding

Designer Probiotics for the treatment of intestinal infection and inflammationR01DK113599 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GARRETT, WENDY S., LEONG, JOHN M · 2016 to 2020
$3.7M
Dissecting the means by which type 3 substrates are defined & secretedR01AI128360 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LESSER, CAMMIE · 2019 to 2023
$2.8M
Designer EcN for treatment of solid tumorsR21CA249995 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LESSER, CAMMIE · 2022 to 2023
$440k
NCI NIH HHS R21 CA249995NCI NIH HHS R21CA249995NIAID NIH HHS R01 AI128360NIDDK NIH HHS RO1DK113599the Brit d'Arbeloff Research Scholar award
6 · The paper itself

Abstract

Live biotherapeutic products (LBPs), including engineered bacteria, are rapidly emerging as potential therapeutic interventions. These innovative therapies can serve as live in situ drug delivery platforms for the direct deposition of therapeutic payloads, including complex biologics, at sites of disease. This approach offers a platform likely to enhance therapeutic efficacy and decrease off-target side effects. LBPs also can likely be distributed at a relatively low price point, as their production can be economically scaled up. LBPs represent an exciting new means for ensuring healthy lives and promoting well-being for all ages, aligning with the World Health Organization's sustainable development goal 3.

Indexed as

BacteriaBiological ProductsBiological TherapyDrug Delivery SystemsHumansMicroorganisms, Genetically-ModifiedBiological Productsengineered bacterialive biotherapeutic productssmart microbes

Identifiers

PMID39579048
PMCPMC11584976

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.