ArticleGenetics2025
MalKinID: A classification model for identifying malaria parasite genealogical relationships using identity-by-descent.
Article in Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Benchmarking and optimization of methods for the detection of identity-by-descent in high-recombiningeLife · 2025Article
- Potential and pitfalls of using identity-by-descent for malaria genomic surveillance.Trends in parasitology · 2025Review
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11 authors.
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Abstract
Pathogen genomics is a powerful tool for tracking infectious disease transmission. In malaria, identity-by-descent is used to assess the genetic relatedness between parasites and has been used to study transmission and importation. In theory, identity-by-descent can be used to distinguish genealogical relationships to reconstruct transmission history or identify parasites for QTL experiments. MalKinID (Malaria Kinship Identifier) is a new classification model designed to identify genealogical relationships among malaria parasites based on genome-wide identity-by-descent proportions and identity-by-descent segment distributions. MalKinID was calibrated to the genomic data from 3 laboratory-based genetic crosses (yielding 440 parent-child and 9060 full-sibling comparisons). MalKinID identified lab-generated F1 progeny with >80% sensitivity and showed that 0.39 (95% CI 0.28, 0.49) of the second-generation progeny of a NF54 and NHP4026 cross were F1s and 0.56 (0.45, 0.67) were backcrosses of an F1 with the parental NF54 strain. In simulated outcrossed importations, MalKinID reconstructs genealogy history with high precision and sensitivity, with F1-scores exceeding 0.84. However, when importation involves inbreeding, such as during serial co-transmission, the precision and sensitivity of MalKinID declined, with F1-scores (the harmonic mean of precision and sensitivity) of 0.76 (0.56, 0.92) and 0.23 (0.0, 0.4) for parent-child and full-sibling and <0.05 for second-degree and third-degree relatives. Disentangling inbred relationships required adapting MalKinID to perform multisample comparisons. Genealogical inference is most powered when (1) outcrossing is the norm or (2) multisample comparisons based on a predefined pedigree are used. MalKinID lays the foundations for using identity-by-descent to track parasite transmission history and for separating progeny for quantitative-trait-locus experiments.
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