Evidence map›Paper›PMID 39579168›Full record

ArticleTissue engineering and regenerative medicine2025

Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants.

Jing Han, Jorine G F Sanders, Lea Andrée, Bart A J A van Oirschot, Adelina S Plachokova, Jeroen J J P van den Beucken, Sander C G Leeuwenburgh, Fang Yang

Abstract read
In one paragraph

Article in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Innovative Smart Materials in Restorative Dentistry.Journal of functional biomaterials · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing HanDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Jorine G F SandersDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Lea AndréeDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Bart A J A van OirschotDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Adelina S PlachokovaDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Jeroen J J P van den BeuckenDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Sander C G LeeuwenburghDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands.
Fang YangDepartment of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Philips Van Leijdenlaan 25, 6525, Nijmegen, The Netherlands. Fang.Yang@Radboudumc.nl.ORCID http://orcid.org/0000-0002-4022-7643

Funding

China Scholarship Council 201909370049Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek 17615
6 · The paper itself

Abstract

backgroundSoft tissue integration (STI) around dental implant abutments is a prerequisite to prevent bacterial invasion and achieve successful dental implant rehabilitation. However, peri-implant STI is a major challenge after dental abutment placement due to alterations in the immune microenvironment upon surgical dental implant installation.

methodsBased on known immunomodulatory effects of zinc, we herein deposited zinc/chitosan/gelatin (Zn/CS/Gel) coatings onto titanium substrates to study their effect on macrophages. First, we exposed macrophages to cell culture media containing different zinc ion (Zn

resultsWe found that Zn

conclusionOur promising results suggest that controlled release of Zn

Indexed as

ChitosanCoated Materials, BiocompatibleDental ImplantsGelatinMacrophagesZincAnimalsCell AdhesionCell ProliferationCytokinesFibroblastsGingivaHumansImmunomodulating AgentsMiceRAW 264.7 CellsChitosanCoated Materials, BiocompatibleCytokinesDental ImplantsGelatinImmunomodulating AgentsZincChitosanGelatinMacrophageSoft tissue integrationZinc ion

Identifiers

PMID39579168
PMCPMC11711843

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.