Evidence map›Paper›PMID 39582571›Full record

ArticleWorld journal of diabetes2024

Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus.

Yi-Bo Tang, Le-Sha Wang, Yi-Hui Wu, Li-Xia Zhang, Lu-Yao Hu, Qi Wu, Meng-Lin Zhou, Zhao-Xia Liang

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In one paragraph

Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi-Bo TangDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Le-Sha WangDepartment of Obstetrics, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China.
Yi-Hui WuDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Li-Xia ZhangDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Lu-Yao HuDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Qi WuDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Meng-Lin ZhouDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
Zhao-Xia LiangDepartment of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China. xiaozaizai@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) women require prenatal care to minimize short- and long-term complications. The mechanism by which exercise during pregnancy affects organ development and whether glucose transporter (GLUT) 1 plays a role in GDM offspring organ development remains unknown.

aimTo determine the effect of exercise during pregnancy on the cardiac, hepatic and renal development of GDM mother's offspring.

methodsPlacenta samples were collected from humans and mice. GDM mouse models were created using streptozotocin along with a GDM with exercise group. The hearts, livers and kidneys of 3- and 8-week-old offspring were collected for body composition analysis and staining. The effects of high glucose levels and hypoxia were investigated using HTR8/SVneo. Transwell and wound-healing assays were performed to assess cell migration. Immunofluorescence accompanied with TUNEL and Ki67 staining was used to explore apoptosis and proliferation.

resultsExercise during pregnancy downregulated the GLUT1 and hypoxia inducible factor-1α expression in placenta from individuals with GDM. Cobalt chloride-induced hypoxia and high glucose levels also significantly decreased migration and apoptosis of HTR8/SVneo cells. In addition, exercise reduced inflammatory cell infiltration in the liver and decreased the tubular vacuolar area in the kidneys of offspring.

conclusionGDM affects the growth and development of organs in offspring. Exercise during pregnancy can reverse adverse effects of GDM on the development of the heart, liver, and kidney in offspring.

Indexed as

ExerciseGestational diabetes mellitusGlucose transporter 1Hypoxia inducible factor-1αOffspringPlacenta

Identifiers

PMID39582571
PMCPMC11580567

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.