Evidence map›Paper›PMID 39583183›Full record

ArticleBone reports2024

Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway.

Mohamed Awad, Elizabeth Taylor-Diaz, Amany Tawfik, Khaled Hussein, Ahmed Elmansi, Mahmoud Elashiry, Ranya Elsayed, Linah Shahoumi, James Borke, William Hill and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamed AwadDental College of Georgia, Augusta University, Augusta, GA, USA.
Elizabeth Taylor-DiazWestern University of Health Sciences, Pomona, CA, USA.
Amany TawfikOakland University, Eye Research Institute, Rochester, MI, USA.
Khaled HusseinDental College of Georgia, Augusta University, Augusta, GA, USA.
Ahmed ElmansiDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Mahmoud ElashiryDental College of Georgia, Augusta University, Augusta, GA, USA.
Ranya ElsayedDental College of Georgia, Augusta University, Augusta, GA, USA.
Linah ShahoumiDental College of Georgia, Augusta University, Augusta, GA, USA.
James BorkeWestern University of Health Sciences, Pomona, CA, USA.
William HillMedical University of South Carolina, Charleston, SC, USA.
Fanglong DongWestern University of Health Sciences, Pomona, CA, USA.
Mohammed E ElsalantyWestern University of Health Sciences, Pomona, CA, USA.

Funding

Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
NIA NIH HHS T32 AG000114
6 · The paper itself

Abstract

Introduction: In this study, we tested the hypothesis that pre-osteoclast signaling is key in triggering post-traumatic angiogenesis in alveolar bone via the SDF-1/CXCR4 pathway. Interruption of osteoclast differentiation through zoledronate (Zol) disrupts the crosstalk between pre-osteoclasts and endothelial cells, hindering the initial angiogenic reaction following dental trauma. This disruption could therefore play a role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ). Methods: The effect of zoledronate on the expression of SDF1 was tested in pre-osteoclasts (POC) in vitro. Then, we tested the effect of pre-osteoclast conditioned medium on HUVEC cell differentiation, migration, tube-formation, and CXCR4 expression and activity in-vitro. Lastly, we quantified the effect of zoledronate treatment on post-traumatic vascular perfusion of alveolar bone, using microCT-angiography and immunohistochemistry. Results: SDF-1 mRNA expression decreased in Zol-treated POCs ( Conclusion: Pre-osteoclasts play a crucial role in the initial angiogenic response in alveolar bone following dental extraction. Disruption of this process may be a predisposing factor to osteonecrosis.

Indexed as

AngiogenesisCXCR4OsteoclastsOsteonecrosisSDF1Zoledronate

Identifiers

PMID39583183
PMCPMC11585646

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.