Evidence map›Paper›PMID 39583875›Full record

ArticleProteoglycan research

Utility of Authentic

Eduardo Stancanelli, Dixy E Green, Katelyn Arnold, Jianxiang Zhang, Deyu Kong, Paul L DeAngelis, Jian Liu

Abstract read
In one paragraph

Article in Proteoglycan research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eduardo StancanelliDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID 0000-0002-6006-2209
Dixy E GreenDepartment of Biochemistry and Physiology The University of Oklahoma Health Science Center Oklahoma City Oklahoma USA.ORCID 0000-0002-6237-0889
Katelyn ArnoldDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID 0000-0002-1750-1253
Jianxiang ZhangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID 0000-0002-1963-456X
Deyu KongDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID 0000-0002-9154-5967
Paul L DeAngelisDepartment of Biochemistry and Physiology The University of Oklahoma Health Science Center Oklahoma City Oklahoma USA.ORCID 0000-0002-8843-1344
Jian LiuDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA.ORCID 0000-0001-8552-1400

Funding

ApoE and Heparan Sulfate Interaction in Alzheimer’s DiseaseR01AG087305 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI JIAN LIU, Chunyu Wang · 2024 to 2026
$2.3M
Development of analytical methods for glycosaminoglycans from biological sourcesR44GM142304 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI WANG, ZHANGJIE · 2022 to 2023
$2.0M
NIA NIH HHS R01 AG087305NIGMS NIH HHS R44 GM142304
6 · The paper itself

Abstract

Hyaluronan (hyaluronic acid, HA), a key glycosaminoglycan in the extracellular matrix, plays crucial roles in various physiological and pathological processes, including development, tissue hydration, inflammation, and tumor progression. Traditional methods for HA quantification, such as ELISA-like assays, often have limitations in sensitivity and specificity, particularly for lower molecular weight HA. In this work, we introduce a coupled liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method that employs a chemoenzymatically synthesized

Indexed as

13C labeled disaccharidechemoenzymatic synthesisglycosaminoglycanhyaluronic acidLC‐MS/MSquantification

Identifiers

PMID39583875
PMCPMC11582344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.