Evidence map›Paper›PMID 39585034›Full record

ArticlePediatric reports2024

Elevation of NT-proBNP Levels in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Patients with Endotheliopathy.

Kimberly Uchida, Xiaomeng Yuan, Jennifer McArthur, Rebekah Lassiter, Haitao Pan, Dinesh Keerthi, Katherine Tsai, Yvonne Avent, Melissa Hines, Hugo R Martinez and 2 more

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Article in Pediatric reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Kimberly UchidaDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.
Xiaomeng YuanDepartment of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 768 Room S2001, Memphis, TN 38105, USA.ORCID 0000-0002-6435-8525
Jennifer McArthurDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.
Rebekah LassiterDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.ORCID 0000-0002-7562-4577
Haitao PanDepartment of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 768 Room S2001, Memphis, TN 38105, USA.
Dinesh KeerthiDepartment of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 321 Room I4112, Memphis, TN 38105, USA.
Katherine TsaiDivision of Pediatric Cardiology, University of Tennessee Health Science Center, 49 N. Dunlap St. 3rd Floor, Memphis, TN 38103, USA.
Yvonne AventDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.
Melissa HinesDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.
Hugo R MartinezDivision of Pediatric Cardiology, University of Tennessee Health Science Center, 49 N. Dunlap St. 3rd Floor, Memphis, TN 38103, USA.
Amr QudeimatDepartment of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 321 Room I4112, Memphis, TN 38105, USA.
Saad GhafoorDivision of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesHematopoietic stem cell transplantation (HSCT) in pediatric and young adult (YA) patients can lead to endotheliopathy, such as thrombotic microangiopathy (TMA), sinusoidal obstruction syndrome (SOS), and diffuse alveolar hemorrhage (DAH). Natriuretic peptides have been studied as markers of endotheliopathy and critical illness. We hypothesized that an elevation in NT-proBNP was associated with the development of endotheliopathy (DAH, SOS, or TMA) in the first 100 days following HSCT in pediatric and YA patients.

methodsIRB-exempt status was obtained. This retrospective case-control study reviewed HSCT at our institution from 2016 to 2020. Cases were selected based on an endotheliopathy diagnosis in the first 100 days after HSCT. Cases were matched with controls. Baseline and near-event NT-proBNP levels were compared between cases and matched controls. The effect of NT-proBNP levels on developing endotheliopathy was estimated using conditional logistic regression.

resultsSixty-two patients were included (31 cases, 31 controls). Near-event NT-proBNP was significantly higher in cases compared to controls (median: 473 vs. 187 pg/mL,

conclusionsNT-proBNP should be studied further as a biomarker for endotheliopathy in pediatric and YA patients undergoing HSCT. This may be particularly relevant for patients undergoing HSCT for ALL.

Indexed as

diffuse alveolar hemorrhage (DAH)endotheliopathyhematopoietic stem cell transplantation (HSCT)NT-proBNPpediatric intensive care unit (PICU)sinusoidal obstruction syndrome (SOS)thrombotic microangiopathy (TMA)

Identifiers

PMID39585034
PMCPMC11587414

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.