Evidence map›Paper›PMID 39585165›Full record

ReviewPathophysiology : the official journal of the International Society for Pathophysiology2024

Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.

Tania Flores-Bazán, Jeannett Alejandra Izquierdo-Vega, José Antonio Guerrero-Solano, Araceli Castañeda-Ovando, Diego Estrada-Luna, Angélica Saraí Jiménez-Osorio

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathophysiology : the official journal of the International Society for Pathophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tania Flores-BazánÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca P.O. Box 42160, Hidalgo, Mexico.ORCID 0000-0001-5797-7718
Jeannett Alejandra Izquierdo-VegaÁrea Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex-Hacienda de la Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca P.O. Box 42160, Hidalgo, Mexico.ORCID 0000-0002-2561-3693
José Antonio Guerrero-SolanoÁrea Académica de Enfermería, Escuela Superior de Tlahuelilpan, Universidad Autónoma del Estado de Hidalgo, Av. Universidad s/n Centro, Tlahuelilpan P.O. Box 42780, Hidalgo, Mexico.ORCID 0000-0002-9331-9509
Araceli Castañeda-OvandoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km 4.5 s/n, Mineral de la Reforma P.O. Box 42184, Hidalgo, Mexico.ORCID 0000-0003-0759-3198
Diego Estrada-LunaÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca P.O. Box 42160, Hidalgo, Mexico.ORCID 0000-0001-9369-8732
Angélica Saraí Jiménez-OsorioÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca P.O. Box 42160, Hidalgo, Mexico.ORCID 0000-0001-5108-0205

Funding

Universidad Autónoma del Estado de Hidalgo Fondos Estatales Genéricos de la Universidad Autónoma del Estado de Hidalgo, Number 2023-[Amp]-0080.
6 · The paper itself

Abstract

BACKGROUND/

objectivesVitamin D (VD) deficiency has been associated with increased risk of gestational disorders affecting the endocrine system, immune system, and neurodevelopment in offspring. Recent studies have focused on the interaction between toxic elements and micronutrients during pregnancy. This review analyzes the potential relationships between VD levels and heavy metals in pregnant women and their offspring.

methodsA systematic review was conducted according to PRISMA 2020 guidelines, using databases such as PubMed, ScienceDirect, Cochrane Library, and Google Scholar. Boolean operators 'AND' and 'OR' were applied with terms like 'pregnancy', 'vitamin D', 'heavy metals', and 'newborns'.

resultsFrom 4688 articles, 14 studies were selected based on relevance and quality. These studies measured the levels of metals like lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As), in biological samples including maternal blood, umbilical cord blood, placenta tissue, and meconium during different stages of pregnancy, showing an inverse relationship between VD deficiency and heavy metal concentrations, which could be related to the incidence of preterm birth.

conclusionsThe review highlights the importance of maintaining adequate VD levels during pregnancy, suggesting that sufficient VD may mitigate the adverse effects of heavy metal exposure, potentially reducing pregnancy-related complications.

Indexed as

heavy metalspregnancytoxic metalloidsvitamin D deficiency

Identifiers

PMID39585165
PMCPMC11587473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.