Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Saugata DuttaClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.ORCID 0000-0003-4377-5706
Yin ZhuClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.
Sultan AlmuntashiriClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.ORCID 0000-0003-4353-6043
Hong Yong PehDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, United States.
Joaquin ZuñigaLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.ORCID 0000-0002-7143-0281
Duo ZhangClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.ORCID 0000-0003-0361-4174
Payaningal R SomanathClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.ORCID 0000-0003-3017-0230
Gustavo RamírezLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Valeria Irineo-MorenoLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Fabiola Jiménez-JuárezLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.ORCID 0009-0004-7473-0740
Karen López-SalinasLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.ORCID 0009-0004-2813-9845
Nora ReginoLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Paloma CamperoLaboratory of Immunobiology and Genetics and Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Stephen J CrockerDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, United States.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-5579-1108
Xiaoyun WangClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.ORCID 0000-0002-9900-740X
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
The Function and Potential Application of Extracellular Vesicle Derived Clara Cell Protein 16 in Gram-negative Bacterial PneumoniaR56HL163607 · NHLBI · UNIVERSITY OF GEORGIA · PI ZHANG, DUO · 2023 to 2023
$501k
MMP-8 Deficiency Improves Host Responses to Influenza Viral InfectionsF32HL147437 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2019 to 2021
$205k
Mechanistic Insights of TIMP-1 in Influenza Virus InfectionR03AI169063 · NIAID · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2022 to 2023
$151k
Foundation for the National Institutes of Health (FNIH) KL2TR002381 and UL1TR002378HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL147437HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R56HL163607HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI169063NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NHLBI NIH HHS F32 HL147437NHLBI NIH HHS R56 HL163607NIAID NIH HHS R03 AI169063NIA NIH HHS U54 AG062334
6 · The paper itself
Abstract
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a physiologic inhibitor of the matrix metalloproteinases (MMPs), but little is known about the role of TIMP-1 in regulating the pathogenesis of influenza A virus (IAV) infection. Here, we performed both in vivo and in vitro experiments to investigate the regulation and function of TIMP-1 during IAV infection. Specifically, plasma levels of TIMP-1 are significantly increased in human subjects and wild-type (WT) mice infected with 2009 H1N1 IAV compared with levels in uninfected controls. Also, TIMP-1 is strikingly upregulated in PDGFRα positive (PDGFRα
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
PDGFRα-positive cell-derived TIMP-1 modulates adaptive immune responses to influenza A viral infection. · full record | Socratic