Evidence map›Paper›PMID 39585355›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Kidney and blood pressure outcomes 11 years after pediatric critical illness and longitudinal impact of AKI: a prospective cohort study.

Emma H Ulrich, Mariya Yordanova, Catherine Morgan, Kelly Benisty, Teodora Riglea, Louis Huynh, Frédérik Crépeau-Hubert, Erin Hessey, Kelly McMahon, Vedran Cockovski and 2 more

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emma H Ulrich *Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Mariya Yordanova *Faculty of Medicine and Dentistry, McGill University Health Centre, Montreal, QC, Canada.
Catherine MorganDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Kelly BenistyFaculty of Medicine and Dentistry, McGill University Health Centre, Montreal, QC, Canada.
Teodora RigleaCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Louis HuynhFaculty of Medicine and Dentistry, McGill University Health Centre, Montreal, QC, Canada.
Frédérik Crépeau-HubertFaculty of Medicine and Dentistry, McGill University Health Centre, Montreal, QC, Canada.
Erin HesseyDepartment of Pediatrics, Toronto Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, University of Toronto, 686 Bay Street, Room 11.9722, Toronto, ON, M5G 0A4, Canada.
Kelly McMahonFaculty of Medicine and Dentistry, McGill University Health Centre, Montreal, QC, Canada.
Vedran CockovskiDepartment of Pediatrics, Toronto Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, University of Toronto, 686 Bay Street, Room 11.9722, Toronto, ON, M5G 0A4, Canada.
Stella WangDepartment of Pediatrics, Toronto Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, University of Toronto, 686 Bay Street, Room 11.9722, Toronto, ON, M5G 0A4, Canada.
Michael ZappitelliDepartment of Pediatrics, Toronto Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, University of Toronto, 686 Bay Street, Room 11.9722, Toronto, ON, M5G 0A4, Canada. Michael.zappitelli@sickkids.ca.ORCID http://orcid.org/0000-0002-9977-0536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is common in critically ill children and associated with adverse short-term outcomes; however, long-term outcomes are not well described.

methodsThis longitudinal prospective cohort study examined the prevalence of chronic kidney disease (CKD) and hypertension (HTN) 11 vs. 6 years after pediatric intensive care unit (PICU) admission and association with AKI. We examined children (age < 19 years) without pre-existing kidney disease 11 ± 1.5 years after PICU admission at a single center. AKI was defined using serum creatinine criteria. The primary outcome was a composite of CKD or HTN. CKD was defined as estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m

resultsOf 96 children evaluated 11 years after PICU admission, 16% had evidence of CKD or HTN (vs. 28% at 6 years, p < 0.05). Multivariable analysis did not show improvement in outcomes from 6- to 11-year follow-up. eGFR decreased from 6- to 11-year follow-up (adjusted coefficient - 11.7, 95% CI - 17.6 to - 5.9) and systolic and diastolic blood pressures improved. AKI was associated with composite outcome at 6-year (adjusted odds ratio (aOR) 12.7, 95% CI 3.2-51.2, p < 0.001), but not 11-year follow-up (p = 0.31). AKI was associated with CKD (aOR 10.4, 95% CI 3.1-34.7) at 11 years.

conclusionsThis study provides novel data showing that adverse kidney and blood pressure outcomes remain highly prevalent 10 years after critical illness in childhood. The association with AKI wanes over time.

Indexed as

Acute Kidney InjuryCritical IllnessHypertensionRenal Insufficiency, ChronicAdolescentChildChild, PreschoolFemaleHumansInfantIntensive Care Units, PediatricLongitudinal StudiesMalePrevalenceProspective StudiesQuebecAcute kidney injuryChronic kidney diseaseHypertension

Identifiers

PMID39585355

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.