SynthesisJAMA network open2024
Outcomes in Randomized Clinical Trials Testing Changes in Daily Water Intake: A Systematic Review.
Synthesis in JAMA network open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Athlete Hydration: Beyond Performance Toward Long-Term Health.Sports medicine (Auckland, N.Z.) · 2026Article
- Nutritional intervention improved dietary intake among patients receiving methadone maintenance treatment.Drug and alcohol dependence reports · 2026Article
- Multimodal Sentiment and Emotion Analysis Framework for Personalized Health Coaching Messages: Proof-of-Concept Study.JMIR formative research · 2026Article
- Associations between beverage consumption patterns and adiposity and urinary biomarkers among young adults: a multicenter cross-sectional study in China.Frontiers in nutrition · 2026Article
- Water from Food in Young Chinese Adults: Patterns, Determinants, and Public Health Implications: A Cross-Sectional Study Across the Seven Geographic Regions.Foods (Basel, Switzerland) · 2025Article
- Contemporary Review of Overlap in Overactive Bladder Patients with Nephrolithiasis: Fluid Reduction in Overactive Bladder and Associated Factors Related To Nephrolithiasis.Current urology reports · 2025Review
- Water intake, hydration, and weight management: the glass is half-full!Physiology & behavior · 2025Review
- The Influence of Drinking Water Intake on Pollutant Levels in the Human Body: Evidence from NHANES Data.Life (Basel, Switzerland) · 2025Article
- Dietary Habits and Their Correlation with Socio-Demographic Variables Among the Ethnic Hungarian Population of Romania.Nutrients · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Several public recommendations exist regarding the amount of daily water intake, yet the supporting evidence is not clear, and benefits of increasing water consumption are not well-established. Objective: To summarize evidence from randomized clinical trials (RCTs) pertaining to the health-related outcomes associated with increased or decreased daily water consumption. Evidence Review: A systematic search of PubMed, Web of Science, and Embase was performed up to April 6, 2023. Studies were included if they aimed to assess the impact of daily water consumption by any defined amount on any health-related outcome. Findings: Of 1464 records screened, 18 (1%) eligible studies were included in the review. Among eligible studies, 15 (83%) were parallel group RCTs, and 3 (16%) were crossover studies. Interventions in these studies consisted of a recommendation to alter the daily amount of water intake by a specific amount for a predefined period ranging between 4 days and 5 years, while the control groups were mostly asked to maintain their usual intake habits. The studies assessed various populations. Recurring primary end points included weight loss, fasting blood glucose level, headache, urinary tract infection, and nephrolithiasis. Consuming additional water was associated with greater weight loss (range, 44%-100% more than control conditions) and fewer nephrolithiasis events (15 fewer events per 100 participants over 5 years). Single studies suggested benefits related to migraine prevention, urinary tract infection, diabetes control, and hypotension. Ten studies (55%) reported at least 1 positive result, and 8 studies (44%) reported negative results. Conclusions and Relevance: This systematic review found that there is a limited number of clinical trials in the literature assessing the benefits of increasing water intake related to a large variety of health outcomes. While the quality and quantity of evidence is limited, a small number of studies suggested benefits of water intake on weight loss and nephrolithiasis, while single studies raised the possibility of benefits for patients with migraine, urinary tract infection, diabetes, and hypotension. Given the low cost and low adverse-effect profile of water, further well-designed studies should assess benefits in these specific conditions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.