Evidence map›Paper›PMID 39585760›Full record

ReviewPhysiology (Bethesda, Md.)2025

Regulation of Cardiac Function by the Autonomic Nervous System.

Omar A Hafez, Rui B Chang

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Acute effects of binge drinking following aerobic exercise on autonomic and hemodynamic recovery in young men: a randomized crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  2. Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Effect of unmanned aerial vehicle mission difficulty level on pilot's autonomic nervous system.International journal of occupational medicine and environmental health · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Omar A HafezDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States.
Rui B ChangDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0001-6953-2943

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Understand the little brain on the heart: a molecular and functional dissection of the intrinsic cardiac nervous systemDP2HL151354 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2019 to 2019
$2.5M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
HHS | NIH | National Center for Complementary and Integrative Health (OAM) R01AT012041HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) DP2HL151354HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL150449HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM136651NCCIH NIH HHS R01 AT012041NHLBI NIH HHS DP2 HL151354NHLBI NIH HHS R01 HL150449
6 · The paper itself

Abstract

The autonomic nervous system is critical for regulating cardiovascular physiology. The neurocardiac axis encompasses multiple levels of control, including the motor circuits of the sympathetic and parasympathetic nervous systems, sensory neurons that contribute to cardiac reflexes, and the intrinsic cardiac nervous system that provides localized sensing and regulation of the heart. Disruption of these systems can lead to significant clinical conditions. Recent advances have enhanced our understanding of the autonomic control of the heart, detailing the specific neuronal populations involved and their physiologic roles. In this review, we discuss this research at each level of the neurocardiac axis. We conclude by discussing the clinical field of neurocardiology and attempts to translate this new understanding of neurocardiac physiology to the clinic. We highlight the contributions of autonomic dysfunction in prevalent cardiovascular diseases and assess the current status of novel neuroscience-based treatment approaches.

Indexed as

Autonomic Nervous SystemHeartAnimalsCardiovascular DiseasesHumansautonomicheart-brain axisICNSneurocardiacvagus

Identifiers

PMID39585760
PMCPMC13345695

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.