Evidence map›Paper›PMID 39586183›Full record

ReviewSeminars in arthritis and rheumatism2025

The pathogenesis, diagnostic utility and clinical relevance of cutaneous telangiectasia in systemic sclerosis.

Aishwarya Anilkumar, Matthew Wells, Robyn T Domsic, Laura K Hummers, Ami A Shah, John D Pauling

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in arthritis and rheumatism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aishwarya AnilkumarDepartment of Rheumatology, North Bristol NHS Trust, Bristol, UK.
Matthew WellsDepartment of Rheumatology, North Bristol NHS Trust, Bristol, UK.
Robyn T DomsicDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Laura K HummersJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Ami A ShahJohns Hopkins University School of Medicine, Baltimore, MD, USA.
John D PaulingDepartment of Rheumatology, North Bristol NHS Trust, Bristol, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: JohnPauling@nhs.net.

Funding

Harnessing multivariate patient- and population-level disease trajectories to predict major clinical events in sclerodermaK24AR080217 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Ami Aalok Shah · 2022 to 2026
$847k
NIAMS NIH HHS K24 AR080217
6 · The paper itself

Abstract

Cutaneous telangiectasia (Tel) are visible permanently dilated postcapillary dermal venules and are one of the most common disease-specific manifestations of systemic sclerosis (SSc). Telangiectasia have long been recognised for their utility in the diagnosis and classification of SSc, but the clinical and prognostic relevance of these aberrant cutaneous vascular manifestations has been somewhat neglected by clinicians. Similarly, the impact of SSc-Tel on body image dissatisfaction and social discomfort has been under-appreciated. The paucity of evidence-based approaches to management has limited access to potential effective treatments for SSc-Tel. The present review examines the pathogenesis, diagnostic value, impact and clinical relevance of telangiectasia in SSc. We highlight the potentially overlooked prognostic value and clinical utility of SSc-Tel, as part of a broader appraisal of areas of unmet research need.

Indexed as

Scleroderma, SystemicTelangiectasisClinical RelevanceHumansPrognosisSkinBiomarkerClassificationClinical outcome measuresDiagnosisPrognosisRaynaud's phenomenonSystemic sclerosisTelangiectasiaTreatment efficacy

Identifiers

PMID39586183
PMCPMC12922703

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.