Evidence map›Paper›PMID 39586245›Full record

ArticleNeuroendocrinology2024

Hormone Regulation of Corticotropin-Releasing Factor Receptor 1 in the Female Mouse Brain.

Rose M De Guzman, Jason S Jacobskind, Zachary J Rosinger, Krystyna A Rybka, Katherine E Parra, Aya L Caballero, Massoud S Sharif, Nicholas J Justice, Damian G Zuloaga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rose M De GuzmanDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Jason S JacobskindDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Zachary J RosingerDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Krystyna A RybkaDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Katherine E ParraDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Aya L CaballeroDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Massoud S SharifDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.
Nicholas J JusticeCenter for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Sciences Center, Houston, Texas, USA.
Damian G ZuloagaDepartment of Psychology, University at Albany, State University New York, Albany, New York, USA.

Funding

Transformation of the stress response into motor behavior by the external globus pallidusR01MH112768 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JUSTICE, NICHOLAS J · 2017 to 2021
$2.3M
Sex differences in corticotropin releasing factor receptor 1 regulation of stress-associated behaviorsR15MH118692 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ZULOAGA, DAMIAN GABRIEL · 2019 to 2019
$462k
Postpartum regulation of CRFR1 and CRFR2 expression in oxytocin neuronsR03MH132006 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ZULOAGA, DAMIAN GABRIEL · 2023 to 2023
$157k
Androgen Regulation of CRF Receptor 1 as a mediator of stress responsesR03MH134109 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ZULOAGA, DAMIAN GABRIEL · 2023 to 2023
$157k
NIMH NIH HHS R01 MH112768NIMH NIH HHS R03 MH132006NIMH NIH HHS R03 MH134109NIMH NIH HHS R15 MH118692
6 · The paper itself

Abstract

introductionCorticotropin-releasing factor receptor 1 (CRFR1) is a key regulator of neuroendocrine and behavioral stress responses. Previous studies have demonstrated that CRFR1 in certain hypothalamic and preoptic brain areas is modified by chronic stress and during the postpartum period in female mice, although the potential hormonal contributors to these changes are unknown.

methodsThis study focused on determining the contributions of hormones associated with stress and the maternal period (glucocorticoids, prolactin, estradiol/progesterone) on CRFR1 levels using a CRFR1-GFP reporter mouse line and immunohistochemistry.

resultsAdministration of dexamethasone, an agonist of the glucocorticoid receptor, elevated CRFR1 in the anteroventral periventricular nucleus (AVPV/PeN) and paraventricular hypothalamus (PVN) with no changes found in the medial preoptic area (MPOA) or arcuate nucleus. Treatment with prolactin for 5 days elevated CRFR1 levels in the MPOA with no changes in other regions. Finally, we utilized the hormone-simulated pseudopregnancy (HSP) paradigm to mimic changes in estradiol and progesterone across pregnancy and the early postpartum period. Female mice receiving HSP treatment, as well as mice receiving HSP treatment that then underwent 5 days of estrogen withdrawal (EW), showed alterations in CRFR1 relative to control groups that mirrored changes previously reported in postpartum mice. Specifically, CRFR1 levels increased in the AVPV/PeN and decreased in the MPOA and PVN, with no changes found in the arcuate nucleus. HSP- and EW-treated mice also showed decreases in tyrosine hydroxylase-expressing neurons in the AVPV/PeN. DISCUSSION/

conclusionOverall, these hormone-induced changes in stress-regulating CRFR1 neurons may impact behavioral and neuroendocrine stress responses.

Indexed as

BrainProlactinReceptors, Corticotropin-Releasing HormoneAnimalsCRF Receptor, Type 1DexamethasoneEstradiolFemaleGlucocorticoidsMiceMice, Inbred C57BLMice, TransgenicParaventricular Hypothalamic NucleusPregnancyProgesteroneCRF Receptor, Type 1DexamethasoneEstradiolGlucocorticoidsProgesteroneProlactinReceptors, Corticotropin-Releasing HormoneCorticotropin-releasing factorDopamineEstradiolGlucocorticoidPostpartumProgesteroneStress

Identifiers

PMID39586245
PMCPMC11813687

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.