Evidence mapPaperPMID 39586579Full record

ReviewRenal failure2024

Research progress and advances in endoplasmic reticulum stress regulation of acute kidney injury.

Li-Ran Zhu, Wei Cui, Hai-Peng Liu

Abstract readReview
In one paragraph

Review in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li-Ran ZhuAnhui Institute of Pediatric Research, Anhui Provincial Children's Hospital (Children's Hospital of Fudan University Anhui Hospital; Children's Medical Center of Anhui Medical University), Hefei, Anhui, China.
Wei CuiDepartment of Scientific Research and Education, Anhui Provincial Children's Hospital (Children's Hospital of Fudan University Anhui Hospital; Children's Medical Center of Anhui Medical University), Hefei, Anhui, China.
Hai-Peng LiuAnhui Institute of Pediatric Research, Anhui Provincial Children's Hospital (Children's Hospital of Fudan University Anhui Hospital; Children's Medical Center of Anhui Medical University), Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a common and severe clinical disorder in which endoplasmic reticulum (ER) stress plays an important regulatory role. In this review, we summarize the research progress on the relationship between ER stress and AKI. It emphasizes the importance of maintaining a balance between promoting and protecting ER stress during AKI and highlights the potential of ER stress-targeted drugs as a new therapeutic approach for AKI. The article also discusses the need for developing drugs that target ER stress effectively while avoiding adverse effects on normal cells and tissues. The review concludes that with a more comprehensive understanding of ER stress mechanisms and advancements in research techniques, more effective treatment options for AKI can be developed in the future.

Indexed as

Acute Kidney InjuryEndoplasmic Reticulum StressAnimalsHumansAcute kidney injuryendoplasmic reticulumsignaling pathwaytherapeutic approach

Identifiers

PMID39586579
PMCPMC11590187

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.