Evidence mapPaperPMID 39586916Full record

ReviewSkeletal radiology2025

Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT.

Christian Schmidkonz, Torsten Kuwert, Theresa Ida Götz, Andreas Ramming, Armin Atzinger

Abstract readReview
In one paragraph

Review in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  4. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian SchmidkonzDepartment of Nuclear Medicine, Erlangen University Hospital, Erlangen, Germany. c.schmidkonz@oth-aw.de.
Torsten KuwertDepartment of Nuclear Medicine, Erlangen University Hospital, Erlangen, Germany.
Theresa Ida GötzInstitute for Medical Engineering, Ostbayerische Technische Hochschule Amberg-Weiden, Amberg, Germany.
Andreas RammingDepartment of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany.
Armin AtzingerDepartment of Nuclear Medicine, Erlangen University Hospital, Erlangen, Germany.

Funding

German Research Foundation 493624887
6 · The paper itself

Abstract

Imaging molecular processes associated with inflammatory disease has been revolutionized by hybrid imaging using positron emission tomography/computed tomography (PET/CT). PET/CT visualizes metabolic activity as well as protein expression and provides a comprehensive whole-body evaluation. It has the potential to reveal inflammation prior to detection of structural changes in inflammatory joint diseases. FAP is a type II transmembrane glycoprotein overexpressed not only in the stroma of tumors but also in the fibrotic processes of certain immune-mediated disorders. The recent introduction of fibroblast activation protein inhibitors (FAPI) labeled by positron emitters and thus suitable for PET/CT allows to investigate FAP expression in vivo. This review will focus on the use of FAPI-PET/CT for the diagnosis and evaluation of treatment response in inflammatory joint diseases.

Indexed as

ArthritisGelatinasesMembrane ProteinsPositron Emission Tomography Computed TomographySerine EndopeptidasesEndopeptidasesFibroblast Activation Protein AlphaHumansRadiopharmaceuticalsEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsRadiopharmaceuticalsSerine EndopeptidasesFAPIJoint diseasesMolecular imagingPET/CT

Identifiers

PMID39586916
PMCPMC12460390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.