Evidence map›Paper›PMID 39587118›Full record

ArticleScientific reports2024

EIF4A3-induced hsa_circ_0127071 promotes human glomerular mesangial cells senescence via JAK2/STAT5 signaling pathway.

Ying Chen, Xinwang Zhu, Da Sun, Li Yao, Shuang Yang, Lining Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying ChenDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China.
Xinwang ZhuDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China.
Da SunDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China.
Li YaoDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China.
Shuang YangDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China. yrch128@163.com.
Lining WangDepartment of Nephrology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Shenyang, Liaoning, China. lnwang56@163.com.

Funding

The Role and Mechanism of JAK/STAT Pathway Regulation of Autophagy in Renal Aging 81370870
6 · The paper itself

Abstract

Circular RNAs (circRNAs) have garnered attention for their potential involvement in the regulation of cellular aging processes. Exploring the role and mechanism of circRNAs in cellular senescence may help to identify new anti-aging therapeutic targets. In the present study, we investigated the role and regulatory mechanism of hsa_circ_0127071 in renal aging. We employed high-throughput sequencing to assess circRNA expression differences in kidney tissues from young and old groups. qRT-PCR confirmed that the expression of hsa_circ_0127071 in kidney tissue of the old group was significantly higher than that of the young group. Cellular senescence was evaluated using SA-β-Gal staining and Masson's trichrome staining. Using RNA Immunoprecipitation (RIP), RNA Pull-Down Assay (RNA pull down), and Western Blot (WB) to study the interaction between hsa_circ_0127071 and aging related pathway proteins. In this study, we found that the expression of hsa_circ_0127071 in kidney tissue of the old group was significantly higher than that of the young group. Silencing of EIF4A3, a protein involved in the JAK2/STAT5 signaling pathway, was found to delay the aging process. On the basis of silencing EIF4A3 expression, the JAK2/STAT5 signaling pathway was activated by Erythropoietin (EPO) processing, and the senescence of Human glomerular mesangial cells (HGMCs) increased. After treatment with Losartan (LOS), the activity of JAK2/STAT5 pathway was decreased and the aging process of HGMCs was delayed. Our findings demonstrate that hsa_circ_0127071 promotes renal aging through the EIF4A3/JAK2/STAT5 signaling axis, highlighting a novel potential therapeutic target for the management of renal aging and associated disorders.

Indexed as

Cellular SenescenceEukaryotic Initiation Factor-4AJanus Kinase 2Mesangial CellsRNA, CircularSignal TransductionSTAT5 Transcription FactorAdultDEAD-box RNA HelicasesHumansMaleDEAD-box RNA HelicasesEIF4A3 protein, humanEukaryotic Initiation Factor-4AJAK2 protein, humanJanus Kinase 2RNA, CircularSTAT5 Transcription FactorHuman glomerular mesangial cellsRegulatory mechanismRenal agingSignaling pathway

Identifiers

PMID39587118
PMCPMC11589872

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.