Evidence map›Paper›PMID 39587144›Full record

ArticleScientific reports2024

Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice.

Daisuke Katagiri, Shinya Nagasaka, Keiko Takahashi, Suwan Wang, Ambra Pozzi, Roy Zent, Akira Shimizu, Ming-Zhi Zhang, Joachim R Göthert, Toin H van Kuppevelt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Diabetic nephropathy: Role of nitric oxide.Nitric oxide : biology and chemistry · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daisuke Katagiri *Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Shinya Nagasaka *Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Keiko TakahashiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Suwan WangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Ambra PozziDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Roy ZentDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Ming-Zhi ZhangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Joachim R GöthertDepartment of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany.
Toin H van KuppeveltDepartment of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Raymond C HarrisDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA.
Takamune TakahashiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223, MCN, Nashville, TN, 37232, USA. takamune.takahashi@vumc.org.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SANDERS, PAUL W. · 2008 to 2022
$18.3M
The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9M
Matrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7M
Role of CD148 Tyrosine Phosphatase in Diabetic NephropathyR01DK097332 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAKAHASHI, TAKAMUNE · 2012 to 2016
$1.7M
The ILK/PINCH/Parvin complex in renal tubulogenesisI01BX002196 · VA · VETERANS HEALTH ADMINISTRATION · PI ZENT, ROY · 2013 to 2025
–
BLRD VA I01 BX002025BLRD VA I01 BX002196BLRD VA IK6 BX005240Department of Veterans Affairs Merit Award 1I01BX002196Japan Society for the Promotion of Science 23K07687NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK097332NIDDK NIH HHS R01 DK119212NIH HHS DK97332, DK114809, DK069921
6 · The paper itself

Abstract

The pivotal role of endothelial nitric oxide synthase (eNOS) in diabetic nephropathy (DN) has been demonstrated using global eNOS knockout (eNOSGKO) mice. However, the precise role of endothelially expressed eNOS and how its deficiency advances DN are still unclear. Here, we targeted endothelial eNOS expression (E-eNOSKO) after the onset of diabetes using the floxed eNOS and endSCL-CreER

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesGlucuronidaseMice, KnockoutNFATC Transcription FactorsNitric Oxide Synthase Type IIIPodocytesAnimalsHeparanaseMaleMiceGlucuronidaseHeparanaseNFATC Transcription FactorsNitric Oxide Synthase Type IIINos3 protein, mouseDiabetic nephropathyeNOSHeparanaseNFAT2Podocyte

Identifiers

PMID39587144
PMCPMC11589149

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.