Evidence map›Paper›PMID 39587412›Full record

Trial reportDiabetic medicine : a journal of the British Diabetic Association2025

Parental perspectives following the implementation of advanced hybrid closed-loop therapy in children and adolescents with type 1 diabetes and elevated glycaemia.

Sin-Ting Tiffany Lai, Sara E Styles, Alisa Boucsein, Yongwen Zhou, Venus Michaels, Craig Jefferies, Esko Wilshire, Martin I De Bock, Benjamin J Wheeler

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sin-Ting Tiffany LaiDepartment of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0003-1046-9454
Sara E StylesDepartment of Human Nutrition, University of Otago, Dunedin, New Zealand.
Alisa BoucseinDepartment of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Yongwen ZhouDepartment of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-0558-6712
Venus MichaelsDepartment of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Craig JefferiesPaediatric Endocrinology, Starship Children's Health, Te Whatu Ora, Health NZ, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-0541-6094
Esko WilshireDepartment of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand.
Martin I De BockDepartment of Paediatrics, University of Otago, Christchurch, New Zealand.
Benjamin J WheelerDepartment of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0003-3348-5238

Funding

The CO-PILOT trial was funded by Lions New Zealand District 202F, Lloyd Morgan Lions Clubs Charitable Trust, Otago Southland Diabetes Research Trust, Lottery Grants Board (grant number R-LHR-2023-215456), The Bowen Family, Spinal Cord Society of New Zealand, University of Otago Wellington, and Starship Foundation (grant number SF4374), with hardware and limited financial support from Medtronic.
6 · The paper itself

Abstract

aimsTo identify from a parental perspective facilitators and barriers of effective implementation of advanced hybrid closed-loop (AHCL) therapy in children and adolescents with type 1 diabetes (T1D) with elevated glycaemia.

methodsSemi-structured interviews were conducted with parents of participants while in a post-trial extension phase of the CO-PILOT randomized controlled trial. The Capability, Opportunity, Motivation, Behaviour Model and Theoretical Domain Framework informed the interviews and framework analysis.

resultsEleven parents of 9 children and adolescents were interviewed. The median age of their children and adolescents was 14.2 years (IQR 13.3-14.7) with median HbA1c 78 mmol/mol (IQR 75-86) (9.3% IQR 9-10) before starting AHCL. Facilitators of implementing AHCL therapy included the following: (1) knowledge acquired from training, (2) establishing routines and action plans, (3) remote glucose monitoring, (4) achievement of glycaemic goals through automation, (5) children/adolescents' capability to use AHCL independently, (6) improved outcomes incentivized continued AHCL, (7) optimism about sustained improvements and (8) social support from healthcare providers, school staff, peers and parents. Barriers to AHCL implementation included the following: (1) challenges with device usability, (2) need for technical support, (3) forgotten knowledge and skills, (4) non-adherence to best practices, (5) negative social influences, (6) physical and psychosocial burden and (7) negative emotions.

conclusionsThis study provides comprehensive insights into parental perspectives of influences on implementing AHCL therapy in children and adolescents with elevated glycaemia. As parents remain key partners in diabetes care, these findings inform successful implementation of AHCL and development of future diabetes technology.

Indexed as

Diabetes Mellitus, Type 1Hypoglycemic AgentsInsulinInsulin Infusion SystemsParentsAdolescentBlood GlucoseBlood Glucose Self-MonitoringChildFemaleGlycated HemoglobinGlycemic ControlHumansMalePancreas, ArtificialBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinadvanced hybrid closed loopartificial pancreasautomated insulin deliverychildren and adolescentparentstype 1 diabetes

Identifiers

PMID39587412
PMCPMC11823305

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.