ArticleBMC pulmonary medicine2024
Significance of respiratory virus coinfection in children with Mycoplasma pneumoniae pneumonia.
Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Clinical and laboratory features of pediatric Mycoplasma pneumoniae Pneumonia with viral versus bacterial co-infection.Italian journal of pediatrics · 2026Article
- Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune-Inflammatory Indicators in Children With Mycoplasma pneumoniae Pneumonia.Journal of clinical laboratory analysis · 2026Article
- Epidemiological characteristics and seasonal dynamics of six respiratory pathogens in children: a 2-year retrospective cross-sectional study in Chengdu, China.BMC pediatrics · 2026Article
- Clinical characteristics, risk factors, and pathogen spectrum of mixed infections in children withMicrobiology spectrum · 2026Article
- Pediatric tracheostomy-associated respiratory infections: an evolving paradigm.Current opinion in pediatrics · 2026Review
- Coinfection Patterns ofInternational journal of molecular sciences · 2026Article
- Correlation analysis of serum CHI3L1, HMGB1, and CD62E detection with the prognosis of Mycoplasma pneumoniae in children.Journal of medical biochemistry · 2026Article
- Impact of pathogen co-detection on disease severity and clinical outcomes in children with Mycoplasma pneumoniae pneumonia.World journal of pediatrics : WJP · 2026Article
- Associated factors of microorganisms causing lower respiratory tract infections in children hospitalized between 2019 and 2022 in a private hospital in Lima, PerúBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Epidemiological characteristics of six respiratory pathogens in respiratory infections in Fuzhou, China.Respiratory research · 2026Article
- Clinical utility of the targeted next-generation sequencing for detection of Mycoplasma pneumoniae and antimicrobial resistance genes for adults.BMC infectious diseases · 2026Article
- Clinical prediction model of Mycoplasma pneumoniae pneumonia combined with influenza virus infection in pediatric patients in Gansu, China.BMC infectious diseases · 2026Article
- Genomic surveillance of the pneumonia outbreak caused byFrontiers in cellular and infection microbiology · 2026Article
- Age-related heterogeneity in diagnosis-coded pediatricFrontiers in public health · 2026Article
- Article
- Admission-time immunologic patterns in hospitalized children withFrontiers in pediatrics · 2026Article
- Designing a broad-spectrum multi-epitope vaccine against influenza A andFrontiers in public health · 2026Article
- Clinical characteristics analysis of pertussis and Mycoplasma pneumoniae infection in children.Frontiers in cellular and infection microbiology · 2026Article
- Comprehensive study of community acquiredWorld journal of clinical pediatrics · 2025Article
- Influenza A Virus andInternational journal of molecular sciences · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMycoplasma pneumoniae is a major causative pathogen in community-acquired pneumonia. Respiratory viral coinfections in children with Mycoplasma pneumoniae pneumonia (MPP) are not uncommon and cause severe clinical manifestations. This study aims to investigate the impacts of viral coinfection in MPP patients and hopes to offer novel insights for discriminating between MPP and MPP coinfection.
methodsThis study recruited 748 children hospitalized for MP pneumonia between January 2021 and October 2023. Patients were classified into two groups: MPP coinfected with respiratory virus group and MPP group. All children underwent polymerase chain reaction testing for respiratory pathogens. Baseline clinical features and demographic data were obtained retrospectively through medical records.
resultsThe retrospective study included 748 patients, with a viral coinfection rate of 38.75%. Patients in the MPP coinfected with respiratory virus group have a higher disease burden than those in the non-coinfection group. Our findings indicate that patients with Mycoplasma pneumonia co-infected with respiratory viruses had longer hospital stays and prolonged fever post-admission, as well as more severe conditions and a higher incidence of extrapulmonary complications. MPP coinfection was associated with the following factors: patients with extrapulmonary complications of gastroenteritis (OR = 4.474, 95%CI = 1.733-11.554, P = 0.002), longer hospital stay (OR = 1.109, 95%CI = 1.012-1.217, P = 0.027), longer days of fever after admission (OR = 1.215 95%CI = 1.006-1.469, P = 0.043), elevated white blood cell count (OR = 1.332 95%CI = 1.082-1.640, P = 0.007), decreased neutrophil count (OR = 0.768 95%CI = 0.602-0.981, P = 0.035), higher fibrinogen levels (OR = 1.652 95%CI = 1.138-2.398, P = 0.008), and raised lactate dehydrogenase levels (OR = 1.007 95%CI = 1.003-1.011, P = 0.001).
conclusionsWe determined the clinical significance of respiratory viral coinfection in children with MPP. Timely identification of MPP coinfection and provision of early and comprehensive therapeutic measures are vital in shortening the disease severity and improving prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.