Evidence map›Paper›PMID 39588921›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Liver-gut axis signaling regulates circadian energy metabolism in shift workers.

Zhenning Yang, Helmut Zarbl, Bo Kong, Rulaiha Taylor, Kathleen Black, Howard Kipen, Veronia Basaly, Mingzhu Fang, Grace L Guo

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. SIRT1: Protean roles at the nexus of health, disease, and therapeutics.Journal of cell communication and signaling · 2026
    Article
  3. Review
  4. Review
  5. Circadian IOP Rhythm in Rats Is Driven by Neural Signals From the Brain.Investigative ophthalmology & visual science · 2026
    Article
  6. Article
  7. Review
  8. Liver-gut axis signaling regulates circadian energy metabolism in shift workers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenning YangDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0003-0989-5544
Helmut ZarblEnvironmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-9491-7324
Bo KongDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-8200-7817
Rulaiha TaylorDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-0561-3653
Kathleen BlackEnvironmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-1165-4304
Howard KipenEnvironmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0001-6608-3126
Veronia BasalyDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-1830-4809
Mingzhu FangEnvironmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0001-5864-0519
Grace L GuoDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.ORCID 0000-0002-2666-0635

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activationR01GM135258 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2020 to 2023
$1.4M
Altered NAD+-dependent Sirt1 as a biomarker of Circadian disruption by shift workR21ES026802 · NIEHS · RBHS-SCHOOL OF PUBLIC HEALTH · PI FANG, MINGZHU · 2017 to 2018
$437k
Differential roles of FXR and FGF15 in liver fibrosis developmentR21ES029258 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2018 to 2019
$426k
The impact of bile acid homeostasis on hepatic xenobiotic receptorsF31DK122725 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI RIZZOLO, DANIEL · 2019 to 2020
$62k
Role of Intestinal Bile Acid Signaling in Liver DiseasesI01BX002741 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI GRACE L GUO · 2018 to 2026
–
BLRD VA I01 BX002741Department of Veteran Affairs BX002741HHS | National Institutes of Health (NIH) DK122725HHS | National Institutes of Health (NIH) ES007148HHS | National Institutes of Health (NIH) ES029258HHS | National Institutes of Health (NIH) GM093854HHS | National Institutes of Health (NIH) GM135258HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) P30ES005022HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) R21ES026802NIDDK NIH HHS F31 DK122725NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R21 ES026802NIEHS NIH HHS R21 ES029258NIEHS NIH HHS T32 ES007148NIGMS NIH HHS K12 GM093854NIGMS NIH HHS R01 GM135258
6 · The paper itself

Abstract

Circadian rhythm is critical to maintaining the whole-body metabolic homeostasis of an organism. Chronic disruption of circadian rhythm by shift work is an important risk factor for metabolic diseases. Fibroblast growth factor 15/19 (FGF15/19), a key component in the liver-gut axis, potently suppresses bile acid (BA) synthesis and improves insulin sensitivity. FGF15/19 emerges as a novel pharmaceutical target for prevention and treatment of metabolic diseases. The nicotinamide adenine dinucleotide (NAD

Indexed as

Circadian RhythmEnergy MetabolismFibroblast Growth FactorsLiverShift Work ScheduleSignal TransductionSirtuin 1AdultAnimalsBile Acids and SaltsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutBile Acids and SaltsFGF19 protein, humanFibroblast Growth FactorsSIRT1 protein, humanSirtuin 1circadian clockfibroblast growth factor 15/19 (FGF15/19)shift worksirtuin 1 (SIRT1)

Identifiers

PMID39588921
PMCPMC11590413

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.