Evidence map›Paper›PMID 39589222›Full record

ArticleStem cells translational medicine2025

Endostatin-expressing endometrial mesenchymal stem cells inhibit angiogenesis in endometriosis through the miRNA-21-5p/TIMP3/PI3K/Akt/mTOR pathway.

Yan Cheng, Qiuyan Guo, Yulei Cheng, Dejun Wang, Liyuan Sun, Tian Liang, Jing Wang, Han Wu, Zhibin Peng, Guangmei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan ChengDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Qiuyan GuoDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Yulei ChengDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta T6G 2G1, Canada.
Dejun WangDepartment of Obstetrics and Gynecology Ultrasound, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Liyuan SunDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Tian LiangDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Jing WangDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Han WuDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.
Zhibin PengCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157, Baojian Road, Nangang District, Harbin 150081, Heilongjiang, China.
Guangmei ZhangDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China.ORCID 0000-0002-4014-8646

Funding

China Postdoctoral Science Foundation 2018M640308First Affiliated Hospital of Harbin Medical University 2021Y03Key Research and Development Program of Heilongjiang Province of China GA21C008National Natural Science Foundation of China 82101725
6 · The paper itself

Abstract

Endometriosis is a chronic inflammatory and neoangiogenic disease. Endostatin is one of the most effective inhibitors of angiogenesis. Mesenchymal stem cells (MSCs) have been investigated as compelling options for cell therapy. However, the effect and mechanism of action of endostatin-expressing endometrial MSCs (EMSCs) in endometriosis are unclear. Here, EMSCs were genetically modified to overexpress endostatin (EMSCs-Endo). A reduction in the angiogenic capacity of HUVECs was observed in vitro after treatment with EMSCs-Endo. EMSCs-Endo significantly suppressed endometriotic lesion growth in vivo. The limited efficacy was associated with suppressed angiogenesis. The miRNA-21-5p level and the levels of p-PI3K, p-mTOR, and p-Akt in HUVECs and mouse endometriotic lesions significantly decreased after treatment with EMSCs-Endo, whereas TIMP3 expression significantly increased. In summary, targeted gene therapy with EMSCs-Endo is feasible, and its efficacy in regulating endometriosis can be attributed to the inhibition of angiogenesis, suggesting that EMSCs could be used as promising vehicles for targeted gene therapy.

Indexed as

EndometriosisEndometriumEndostatinsMesenchymal Stem CellsMicroRNAsNeovascularization, PathologicAngiogenesisAnimalsFemaleHumansHuman Umbilical Vein Endothelial CellsMesenchymal Stem Cell TransplantationMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionEndostatinsMicroRNAsMIRN21 microRNA, humanMTOR protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTIMP3 protein, humanTissue Inhibitor of Metalloproteinase-3TOR Serine-Threonine Kinasesangiogenesisendometriosisendostatinsgene therapymesenchymal stem cells

Identifiers

PMID39589222
PMCPMC11878778

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.