Evidence map›Paper›PMID 39589256›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration.

Barbara Zhao, Jacob Socha, Andrea Toth, Sharlene Fernandes, Helen Warheit-Niemi, Brandy Ruff, Gurjit K Khurana Hershey, Kelli L VanDussen, Daniel Swarr, William J Zacharias

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Barbara ZhaoPerinatal Institute.
Jacob SochaDivision of Gastroenterology, Hepatology, and Nutrition, and.
Andrea TothPerinatal Institute.
Sharlene FernandesPerinatal Institute.
Helen Warheit-NiemiPerinatal Institute.
Brandy RuffDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; and.
Gurjit K Khurana HersheyDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; and.
Kelli L VanDussenDivision of Developmental Biology.
Daniel SwarrPerinatal Institute.
William J ZachariasPerinatal Institute.ORCID 0000-0002-2643-0610

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Dynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8M
Defining PRC2 complex epigenomic control in alveolar progenitor cellsR01HL166245 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI William John Zacharias · 2023 to 2026
$2.3M
Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.R01HL156860 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA, ZACHARIAS, WILLIAM JOHN · 2021 to 2025
$1.9M
Mechanistic evaluation of a novel Wnt-responsive adult alveolar epithelial progenitor population during regeneration after diffuse alveolar damageK08HL140178 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZACHARIAS, WILLIAM JOHN · 2018 to 2022
$815k
NHLBI NIH HHS K08 HL140178NHLBI NIH HHS R01 HL156860NHLBI NIH HHS R01 HL166245NHLBI NIH HHS T32 HL007752NIAID NIH HHS U01 AI150748NIGMS NIH HHS T32 GM063483NIH HHS AI150748NIH HHS GM063483NIH HHS HL007752NIH HHS HL140178NIH HHS HL 156860
6 · The paper itself

Abstract

Lung epithelial progenitors use a complex network of known and predicted transcriptional regulators to influence early lung development. In this study, we evaluated the function of one predicted regulator, CUX1, that we identified from transcriptional regulatory analysis of the SOX9

Indexed as

Homeodomain ProteinsLungOrganogenesisRegenerationRepressor ProteinsAnimalsGene Expression Regulation, DevelopmentalMiceMice, KnockoutNuclear ProteinsPulmonary AlveoliSOX9 Transcription FactorTranscription FactorsCux1 protein, mouseHomeodomain ProteinsNuclear ProteinsRepressor ProteinsSOX9 Transcription FactorTranscription Factorslung developmentlung repairtranscriptional regulatory network

Identifiers

PMID39589256
PMCPMC12143410

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.