Evidence map›Paper›PMID 39589518›Full record

ArticleEuropean journal of nutrition2024

Lactobacillus reuteri TISTR 2736 alleviates type 2 diabetes in rats via the hepatic IRS1/PI3K/AKT signaling pathway by mitigating oxidative stress and inflammatory mediators.

Kamonthip Pakaew, Pennapa Chonpathompikunlert, Navinee Wongmanee, Worarat Rojanaverawong, Jaruwan Sitdhipol, Punnathorn Thaveethaptaikul, Natthawut Charoenphon, Wanthanee Hanchang

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kamonthip PakaewDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Pennapa ChonpathompikunlertBiodiversity Research Centre (BRC), Thailand Institute of Scientific and Technological Research (TISTR), Pathumthani, 12120, Thailand.
Navinee WongmaneeDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Worarat RojanaverawongDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Jaruwan SitdhipolBiodiversity Research Centre (BRC), Thailand Institute of Scientific and Technological Research (TISTR), Pathumthani, 12120, Thailand.
Punnathorn ThaveethaptaikulBiodiversity Research Centre (BRC), Thailand Institute of Scientific and Technological Research (TISTR), Pathumthani, 12120, Thailand.
Natthawut CharoenphonDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Wanthanee HanchangDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand. wanthaneeh@nu.ac.th.ORCID http://orcid.org/0000-0002-8289-7266

Funding

Naresuan University (NU) and National Science, Research and Innovation Fund (NSRF) R2566B050Thailand Institute of Scientific and Technological Research (TISTR) Thailand Institute of Scientific and Technological Research (TISTR)
6 · The paper itself

Abstract

purposeThis study investigated the beneficial effects of Lactobacillus reuteri TISTR 2736 on glucose homeostasis, carbohydrate metabolism, and the underlying mechanisms of its actions in type 2 diabetic (T2D) rats.

methodsA rat model of T2D was established by a combination of a high-fat diet and streptozotocin. The diabetic rats were treated daily with L. reuteri TISTR 2736 (2 × 10

resultsThe results demonstrated that treatment with L. reuteri TISTR 2736 significantly ameliorated fasting blood glucose and glucose intolerance, and improved insulin sensitivity indices in the diabetic rats. The hepatic histopathology was improved with L. reuteri TISTR 2736 treatment, which was correlated with a reduction of hepatic lipid profiles. L. reuteri TISTR 2736 significantly reduced glycogen content, fructose 1,6-bisphosphatase activity, and phosphoenolpyruvate carboxykinase 1 protein expression, and enhanced hexokinase activity in the diabetic liver. The downregulation of IRS1 and phosphorylated IRS1

conclusionBy inhibiting oxidative and inflammatory stress, L. reuteri TISTR 2736 alleviated hyperglycemia and improved carbohydrate metabolism through activating IRS1/PI3K/AKT pathway in the T2D rats.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Insulin Receptor Substrate ProteinsLimosilactobacillus reuteriLiverOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAnimalsBlood GlucoseInflammation MediatorsInsulin ResistanceMaleProbioticsRatsBlood GlucoseInflammation MediatorsInsulin Receptor Substrate ProteinsIrs1 protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCarbohydrate metabolismInsulin signalingLactobacillus reuteriType 2 diabetes

Identifiers

PMID39589518

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.