Trial reportEuropean journal of nutrition2024
Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.
Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Exercise and nutrition as epigenetic regulators of gene expression: an exploratory scoping review with bibliometric analysis.Frontiers in nutrition · 2026Pooled it
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeHigh-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects.
methodsWe recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.0% while fasting). Participants were randomly divided into control (CNT) or HPP rice (HPR) groups and instructed to perform IWT for an additional 4 months while ingesting 75 g dry weight of either white rice or HPP rice, respectively, at every breakfast and dinner. Before and after intervention, [Glc] was measured by continuous glucose monitoring for 5 days, with standardized breakfast on day 5. Methylation of NFKB2 was measured by pyrosequencing.
resultsAfter intervention, mean fasting [Glc] values for 180 min before breakfast over 4 days (days 2-5) marginally decreased in HPR but were not different from CNT (P = 0.17). However, the standard deviation during the period decreased more in HPR than in CNT (P = 0.013). Moreover, total area under the curve (tAUC) for 180 min after breakfast on day 5 decreased more in HPR than in CNT (P = 0.035). The change in tAUC on day 5 after the intervention was negatively correlated with that in NFKB2 gene methylation (P = 0.002).
conclusionHPP rice intake during IWT improved glycemic control with suppressed reduction in NFKB2 gene methylation in hyperglycemic older people. TRIAL REGISTRATION NUMBER AND DATE OF REGISTRATION: UMIN000024390; October 13, 2016.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.