Evidence map›Paper›PMID 39589781›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Associations of circulating T-cell subsets with carotid artery stiffness: the multiethnic study of atherosclerosis.

Theodore M DeConne, Petra Buzkova, Ryan Pewowaruk, Joseph A Delaney, Bruce M Psaty, Russell P Tracy, Margaret F Doyle, Colleen M Sitlani, Alan L Landay, Sally A Huber and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Theodore M DeConneSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0002-9704-6499
Petra BuzkovaDepartment of Biostatistics, University of Washington, Seattle, Washington, United States.
Ryan PewowarukRyan Pewowaruk Research Consulting, Madison, Wisconsin, United States.
Joseph A DelaneyDepartment of Medicine, University of Washington, Seattle, Washington, United States.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, Washington, United States.
Russell P TracyDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.
Margaret F DoyleDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.
Colleen M SitlaniDepartment of Medicine, University of Washington, Seattle, Washington, United States.
Alan L LandayDivision of Geriatrics, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas, United States.
Sally A HuberDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.
Timothy M HughesSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Alain G BertoniDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0002-7503-6273
Adam D GepnerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
Jingzhong DingSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Nels C OlsonDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.ORCID 0000-0003-1192-9969

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8M
Translational Training in Aging and Alzheimer’s Disease Related DisordersT32AG033534 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2009 to 2026
$3.6M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN J · 2020 to 2025
$3.4M
Innate and adaptive immune-cell densities as risk factors for heart failureR01HL135625 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, TRACY, RUSSELL P · 2018 to 2021
$2.8M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-000040HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001079HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001420HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95159HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95160HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95161HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95162HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95163HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95164HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95165HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95166HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95167HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95168HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95169HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL129045HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL120854HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL135625HHS | NIH | National Institute on Aging (NIA) T32AG033534NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R00 HL129045NHLBI NIH HHS R01 HL120854NHLBI NIH HHS R01 HL135625NIA NIH HHS T32 AG033534
6 · The paper itself

Abstract

Arterial stiffness measured by total pulse wave velocity (T-PWV) is associated with an increased risk of multiple age-related diseases. T-PWV can be described by structural (S-PWV) and load-dependent (LD-PWV) arterial stiffening. T-cells have been implicated in arterial remodeling, arterial stiffness, and hypertension in humans and animals; however, it is unknown whether T-cells are risk factors for T-PWV or its components. Therefore, we evaluated the cross-sectional associations of peripheral T-cell subpopulations with T-PWV, S-PWV, and LD-PWV. Peripheral blood T-cells were characterized using flow cytometry, and carotid artery stiffness was measured using B-mode ultrasound to calculate T-PWV at the baseline examination in a participant subset of the Multi-Ethnic Study of Atherosclerosis (MESA,

Indexed as

Carotid ArteriesPulse Wave AnalysisVascular StiffnessAgedAged, 80 and overAtherosclerosisCarotid Artery DiseasesCD8-Positive T-LymphocytesCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsT-Lymphocyte SubsetsUnited Statesagingarterial stiffnessepidemiologyrisk factorsT-cells

Identifiers

PMID39589781
PMCPMC11901338

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.