Evidence map›Paper›PMID 39590652›Full record

ArticleJournal of fungi (Basel, Switzerland)2024

Characterization of a New Hsp110 Inhibitor as a Potential Antifungal.

Cancan Sun, Yi Li, Justin M Kidd, Jizhong Han, Liangliang Ding, Aaron E May, Lei Zhou, Qinglian Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cancan SunDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-1040-6621
Yi LiInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518107, China.
Justin M KiddDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Jizhong HanInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518107, China.
Liangliang DingInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518107, China.
Aaron E MayDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Lei ZhouInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518107, China.
Qinglian LiuDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Structural and Functional Studies of Hsp70 Molecular ChaperonesR01GM098592 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Qinglian Liu · 2013 to 2026
$4.3M
National Natural Science Foundation of China NSFC #32171150NCATS NIH HHS UL1 TR002649NIGMS NIH HHS R01 GM098592NIH HHS R01GM098592Shenzhen Bay Laboratory S211101001-3Virginia Commonwealth University CCTR Endowment Fund of Virginia Commonwealth UniversityVirginia Commonwealth University Virginia Commonwealth University Bridge awards
6 · The paper itself

Abstract

Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protein homeostasis in eukaryotes. Fungal Hsp110s have emerged as a promising target for innovative antifungal strategies. Notably, 2H stands out as a promising candidate in the endeavor to target Hsp110s and combat fungal infections. Our study reveals that 2H exhibits broad-spectrum antifungal activity, effectively disrupting the in vitro chaperone activity of Hsp110 from

Indexed as

Candida albicansCandida aurisCryptococcus neoformansfungal infectionsHsp110molecular chaperonespharmacokinetic

Identifiers

PMID39590652
PMCPMC11595998

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.