Evidence map›Paper›PMID 39594602›Full record

ArticleCells2024

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Large-Vessel Vasculitis During Active and Inactive Disease Stages Is Associated with the Metabolic Profile, but Not the Macrophage-Related Cytokines: A Proof-of-Concept Study.

Dimitris Anastasios Palamidas, Georgios Kalykakis, Dimitra Benaki, Loukas Chatzis, Ourania D Argyropoulou, Panagiota Palla, Antonia Kollia, Pavlos Kafouris, Marinos Metaxas, Andreas V Goules and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dimitris Anastasios PalamidasDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.
Georgios KalykakisDepartment of Informatics, Ionian University, 49100 Kerkyra, Greece.ORCID 0000-0003-2042-1569
Dimitra BenakiDepartment of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0003-3072-204X
Loukas ChatzisDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.ORCID 0000-0002-2832-0116
Ourania D ArgyropoulouDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.
Panagiota PallaDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.
Antonia KolliaPET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Pavlos KafourisPET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Marinos MetaxasPET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Andreas V GoulesDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.ORCID 0000-0003-4343-0396
Emmanuel MikrosDepartment of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-5984-5169
Konstantinos KambasLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Constantinos D AnagnostopoulosPET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Athanasios G TzioufasDepartment of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.ORCID 0000-0001-6666-8642

Funding

George and Victoria Karelias FoundationSpecial Account for Research Grants, National Kapodistrian University of Athens 10209
6 · The paper itself

Abstract

Giant cell arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The disease presents as an acute inflammatory response with two phenotypes, cranial GCA and large-vessel vasculitis (LV)-GCA, involving the thoracic aorta and its branches. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is among the imaging techniques contributing to diagnosing patients with systemic disease. However, its association with soluble inflammatory markers is still elusive. This proof-of-concept study aims to identify novel soluble serum biomarkers in PET/CT-positive patients with LV-GCA and associate them with active (0 months) and inactive disease (6 months following treatment), in sequential samples. The most-diseased-segment target-to-background ratio (TBR

Indexed as

CytokinesFluorodeoxyglucose F18Giant Cell ArteritisMacrophagesPositron Emission Tomography Computed TomographyAgedAged, 80 and overBiomarkersFemaleHumansMaleMetabolomeMiddle AgedProof of Concept StudyVasculitisBiomarkersCytokinesFluorodeoxyglucose F1818F-FDG PET-CTcytokinesgiant cell arteritislarge vessel vasculitismetabolomics

Identifiers

PMID39594602
PMCPMC11592869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.