Evidence map›Paper›PMID 39594997›Full record

ReviewBiomedicines2024

Modulation of the Immune Environment in Glioblastoma by the Gut Microbiota.

George B H Green, Alexis N Cox-Holmes, Anna Claire E Potier, Gillian H Marlow, Braden C McFarland

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

George B H GreenDepartment of Cell, Developmental and Integrative Biology, Birmingham, AL 35294, USA.ORCID 0000-0001-6389-4919
Alexis N Cox-HolmesDepartment of Cell, Developmental and Integrative Biology, Birmingham, AL 35294, USA.ORCID 0000-0002-8203-2801
Anna Claire E PotierDepartment of Cell, Developmental and Integrative Biology, Birmingham, AL 35294, USA.
Gillian H MarlowDepartment of Cell, Developmental and Integrative Biology, Birmingham, AL 35294, USA.
Braden C McFarlandDepartment of Cell, Developmental and Integrative Biology, Birmingham, AL 35294, USA.

Funding

Employing Humanized Microbiome Mice to Understand Immune Activation and Translational Therapeutic Potential in GlioblastomaR01CA270750 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Braden Cox McFarland · 2023 to 2026
$1.3M
NCI NIH HHS R01 CA270750NIH HHS R01CA270750-01A1
6 · The paper itself

Abstract

Studies increasingly support the role of the gut microbiota in glioma development and treatment, although the exact mechanisms remain unclear. Research indicates that the gut microbiota can influence glioma progression, response to therapies, and the effectiveness of treatments like immunotherapy, with certain microbial compositions being linked to better outcomes. Additionally, the gut microbiota impacts the tumor microenvironment, affecting both tumor growth and the response to treatment. This review will explore glioma, the gut microbiota, and how their interaction shapes glioma development and therapy responses. Additionally, this review examines the influence of gut microbiota metabolites, such as short-chain fatty acids (SCFAs) and tryptophan, on glioma development and treatment. It also explores gut microbiome signaling via pattern recognition receptors, and the role of molecular mimicry between microbial and tumor antigens in glioblastoma, and if these interactions affect glioma development and treatment.

Indexed as

glioblastomagliomamicrobiome

Identifiers

PMID39594997
PMCPMC11591702

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.