Evidence map›Paper›PMID 39595021›Full record

ArticleBiomedicines2024

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer.

Ksenia Lenkova, Rita Khusainova, Raushaniya Minyazeva, Aliya Zaripova, Irina Gilyazova, Natalia Mokrysheva, Ildar Minniakhmetov

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In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ksenia LenkovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Prospekt Oktyabrya Street, 71, 450054 Ufa, Russia.
Rita KhusainovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Prospekt Oktyabrya Street, 71, 450054 Ufa, Russia.ORCID 0000-0002-8643-850X
Raushaniya MinyazevaInternal Medicine Department, Bashkir State Medical University, 450008 Ufa, Russia.
Aliya ZaripovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Prospekt Oktyabrya Street, 71, 450054 Ufa, Russia.ORCID 0000-0001-6975-5151
Irina GilyazovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Prospekt Oktyabrya Street, 71, 450054 Ufa, Russia.ORCID 0000-0001-9499-5632
Natalia MokryshevaEndocrinology Research Centre, Dmitry Ulyanov Street, 11, 117292 Moscow, Russia.
Ildar MinniakhmetovEndocrinology Research Centre, Dmitry Ulyanov Street, 11, 117292 Moscow, Russia.ORCID 0000-0002-7045-8215

Funding

This work was supported by Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2022-310 from 20 April 2022) and partially supported by St. Petersburg State University, ID PURE project: 103964756. This work was supported by Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2022-310 from 20 April 2022) and partially supported by St. Petersburg State University, ID PURE project: 103964756.
6 · The paper itself

Abstract

BACKGROUND/

objectivesCervical cancer (CC) remains a significant global health challenge, characterized by genetic heterogeneity and a complex molecular landscape, both of which contribute to its pathogenesis. This study aimed to investigate germline variants in proto-oncogenes and tumor suppressor genes in cervical cancer patients, with the objective of clarifying their potential role in disease development.

methodsWe utilized a custom next-generation sequencing (NGS) panel targeting 48 genes implicated in oncogenesis. Germline DNA samples from cervical cancer patients were analyzed in order to identify nucleotide sequence alterations. Variants were classified according to pathogenicity and clinical relevance, based on established guidelines.

resultsA total of 148 nucleotide variants were detected within the cohort. Of these, 35 variants (23.6%) were classified as benign. In contrast, 105 variants (70.9%) were identified as variants of uncertain significance (VUSs). Moreover, seven pathogenic or likely pathogenic mutations were discovered, along with the polymorphic variant rs1042522 in the

conclusionsOur findings contribute to expanding our understanding of the molecular genetic landscape of cervical cancer. They emphasize the potential contribution of rare germline mutations to its development and progression. These results highlight the importance of comprehensive genetic screening in order to improve diagnostic and therapeutic approaches for cervical cancer patients.

Indexed as

cancermolecular genetic landscapeoncogenestumor suppressor genes

Identifiers

PMID39595021
PMCPMC11592371

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.