Evidence map›Paper›PMID 39595604›Full record

ArticleBiomolecules2024

Antagonistic Effects of Actin-Specific Toxins on

David B Heisler, Elena Kudryashova, Regan Hitt, Blake Williams, Michelle Dziejman, John Gunn, Dmitri S Kudryashov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

David B HeislerDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-6482-4215
Elena KudryashovaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-1646-1229
Regan HittCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Blake WilliamsDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Michelle DziejmanDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
John GunnCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Dmitri S KudryashovDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1782-3305

Funding

Name Molecular mechanisms of bacterial toxins targeting actin cytoskeletonR01GM114666 · NIGMS · OHIO STATE UNIVERSITY · PI KUDRYASHOV, DMITRI · 2015 to 2025
$3.8M
Novel effector protein functions encoded by T3SS positive V. choleraeR01AI126005 · NIAID · UNIVERSITY OF ROCHESTER · PI DZIEJMAN, MICHELLE · 2017 to 2021
$2.4M
Infectious Disease Institute FundNIAID NIH HHS R01 AI126005NIGMS NIH HHS R01 GM114666NIH HHS R01 AI126005NIH HHS R01 GM114666OSU Public Health Preparedness for Infectious Diseases (PHPID) Fellowship
6 · The paper itself

Abstract

Competition between bacterial species is a major factor shaping microbial communities. It is possible but remains largely unexplored that competition between bacterial pathogens can be mediated through antagonistic effects of bacterial effector proteins on host systems, particularly the actin cytoskeleton. Using

Indexed as

ActinsBacterial ToxinsSalmonella typhimuriumActin CytoskeletonAnimalsBacterial ProteinsHeLa CellsHost-Pathogen InteractionsHumansVibrio choleraeActinsBacterial ProteinsBacterial Toxinsactin cytoskeletonbacterial competitioneffector proteinsSalmonella

Identifiers

PMID39595604
PMCPMC11591686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.