Evidence map›Paper›PMID 39595950›Full record

ArticleInternational journal of molecular sciences2024

Iodinated PSMA Ligands as XFI Tracers for Targeted Cell Imaging and Characterization of Nanoparticles.

Svenja Kerpa, Malte Holzapfel, Theresa Staufer, Robert Kuhrwahl, Marina Mutas, Stefan Werner, Verena R Schulze, Pascal Nakielski, Neus Feliu, Elke Oetjen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Svenja KerpaDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.
Malte HolzapfelFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.ORCID 0009-0005-8373-8776
Theresa StauferUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.ORCID 0000-0001-6658-5775
Robert KuhrwahlUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.
Marina MutasFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.
Stefan WernerDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Verena R SchulzeFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.ORCID 0000-0003-1533-708X
Pascal NakielskiFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.
Neus FeliuFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.
Elke OetjenInstitute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.ORCID 0000-0001-7807-6652
Jannis HaakUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.
Florian ZieglerUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.
Rasmus BuchinUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.ORCID 0009-0001-9896-8401
Jili HanDepartment of Physics, Universität Hamburg and Center for Hybrid Nanostructures (CHyN), Luruper Chaussee 149, 22761 Hamburg, Germany.
Wolfgang J ParakDepartment of Physics, Universität Hamburg and Center for Hybrid Nanostructures (CHyN), Luruper Chaussee 149, 22761 Hamburg, Germany.ORCID 0000-0003-1672-6650
Florian GrünerUniversity of Hamburg and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.ORCID 0000-0001-8382-9225
Wolfgang MaisonDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.

Funding

Deutsche Forschungsgemeinschaft EXC 2056 - project ID 390715994Fraunhofer Internal Program Attract 178-600040Mildred Scheel Caner Career Center HaTriCS4 and the German Cancer Aid INST 152/933-1
6 · The paper itself

Abstract

Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Despite this, current diagnostic tools are still not satisfactory, lacking sensitivity for early-stage or single-cell diagnosis. This study describes the development of small-molecule tracers for the well-known tumor marker prostate-specific membrane antigen (PSMA). These tracers contain a urea motif for PSMA-targeting and iodinated aromatic moieties to allow detection via X-ray fluorescence imaging (XFI). Tracers with a triiodobenzoyl moiety allowed the specific targeting and successful imaging of PSMA+ cell lines with XFI. The XFI-measured uptake of 7.88 × 10

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IIQuantum DotsCell Line, TumorHumansLigandsMaleNanoparticlesOptical ImagingProstatic NeoplasmsAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILigandsprostate cancerPSMAquantum dotstumor targetingXFI

Identifiers

PMID39595950
PMCPMC11594147

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.