Evidence map›Paper›PMID 39596138›Full record

ReviewInternational journal of molecular sciences2024

Matrikines of Sea Cucumbers: Structure, Biological Activity and Mechanisms of Action.

Aleksandr Popov, Emma Kozlovskaya, Tatyana Rutckova, Olga Styshova, Vyacheslav Makhankov, Aleksey Vakhrushev, Dmitry Hushpulian, Irina Gazaryan, Oksana Son, Ludmila Tekutyeva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Sea CucumberMarine drugs · 2025
    Article
  3. Microstructure of Sea CucumberGels (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandr PopovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Emma KozlovskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Tatyana RutckovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Olga StyshovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Vyacheslav MakhankovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Aleksey VakhrushevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Dmitry HushpulianFaculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya Str., Moscow 117997, Russia.ORCID 0000-0002-2171-9896
Irina GazaryanFaculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya Str., Moscow 117997, Russia.
Oksana SonDepartment of Bioeconomy and Food Security, School of Economics and Management, Far Eastern Federal University, Vladivostok 690922, Russia.
Ludmila TekutyevaDepartment of Bioeconomy and Food Security, School of Economics and Management, Far Eastern Federal University, Vladivostok 690922, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrikines (MKs), the products of enzymatic fragmentation of various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis and autophagy, and are also effectively used in biomedicine and functional nutrition. Recently, there has been great interest in the structural features and biological activity of MKs from various sources. This review summarized and analyzed the results of modern research on MKs from sea cucumbers, primarily from trepang (MKT). Particular attention is paid to the analysis of the existing knowledge on the antioxidant, anti-inflammatory and adaptogenic activities of these MKs and the possible mechanisms of their protective action.

Indexed as

AntioxidantsSea CucumbersAnimalsAnti-Inflammatory AgentsApoptosisAutophagyCell ProliferationExtracellular Matrix ProteinsHumansAnti-Inflammatory AgentsAntioxidantsExtracellular Matrix Proteinsbiological activityenzymatic transformationmatrikines (MKs)sea cucumberstrepang Apostichopus japonicus MKs (MKT)

Identifiers

PMID39596138
PMCPMC11594131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.