Evidence map›Paper›PMID 39596152›Full record

ArticleInternational journal of molecular sciences2024

The Expression of HPV-16 E5 Oncoprotein Impacts the Transcript Profiles of FGFR2 and EMT-Related Genes in Preneoplastic Anal Epithelium Lesions.

Salvatore Raffa, Vanessa Mancini, Deborah French, Francesca Rollo, Maria Benevolo, Eugenia Giuliani, Maria Gabriella Donà, Danilo Ranieri, Francesca Belleudi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salvatore RaffaDepartment of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.ORCID 0000-0001-9501-7638
Vanessa ManciniDepartment of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.ORCID 0000-0001-5176-2724
Deborah FrenchDepartment of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.
Francesca RolloPathology Department, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0003-2724-872X
Maria BenevoloPathology Department, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0003-1994-0935
Eugenia GiulianiSexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.ORCID 0000-0002-9721-4173
Maria Gabriella DonàSexually Transmitted Infection/Human Immunodeficiency Virus Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.ORCID 0000-0003-3250-1726
Danilo RanieriDepartment of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy.ORCID 0000-0001-5039-0834
Francesca BelleudiDepartment of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.

Funding

Ministero dell'università e Ricerca PRIN 2022-Prot. 20227YTZE3
6 · The paper itself

Abstract

Anal Squamous Cell Carcinoma (SCCA) is a rare Human Papillomavirus type 16 (HPV16)-associated carcinoma whose pathogenesis is still poorly understood. Recent studies based on biopsy and Next Generation Sequencing (NGS) approaches have linked the viral episomal status to aggressive SCCA phenotypes, suggesting a potential role of the 16E5 oncoprotein in tumor development. Our previous findings indicated that 16E5 induces Fibroblast Growth Factor Receptor 2 (FGFR2) isoform switching, aberrant mesenchymal FGFR2c expression, Epithelial Mesenchymal Transition (EMT), and cell invasion in various in vitro human keratinocyte models, as well as in the in vivo context of cervical Low-grade Squamous Intraepithelial Lesions (LSILs). To further explore the role of 16E5 in epithelial carcinogenesis, this study aims to investigate the molecular profile in HPV-related anal lesions. The results showed a significant positive correlation between 16E5 and FGFR2c, as well as 16E5 or FGFR2c and key EMT-related transcription factors, particularly in the group of HPV16 positive anal samples not containing without high grade lesions. Additionally, by coupling the molecular analysis with an interactome investigation, we hypothesized a potential functional interplay between the Ca

Indexed as

Anus NeoplasmsEpithelial-Mesenchymal TransitionHuman papillomavirus 16Oncogene Proteins, ViralReceptor, Fibroblast Growth Factor, Type 2AdultAgedCarcinoma, Squamous CellFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPapillomavirus InfectionsPrecancerous ConditionsTranscriptomeFGFR2 protein, humanoncogene protein E5, Human papillomavirus type 16Oncogene Proteins, ViralReceptor, Fibroblast Growth Factor, Type 2Viroporin ProteinsE5epithelial–mesenchymal transitionFGFR2cHPV16TRPA1

Identifiers

PMID39596152
PMCPMC11593544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.