Evidence mapPaperPMID 39596237Full record

ReviewInternational journal of molecular sciences2024

The Potential of Mesenchymal Stem/Stromal Cells in Diabetic Wounds and Future Directions for Research and Therapy-Is It Time for Use in Everyday Practice?

Damian Sieńko, Ilona Szabłowska-Gadomska, Anna Nowak-Szwed, Stefan Rudziński, Maksymilian Gofron, Przemysław Zygmunciak, Małgorzata Lewandowska-Szumieł, Wojciech Stanisław Zgliczyński, Leszek Czupryniak, Beata Mrozikiewicz-Rakowska

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Damian SieńkoDepartment of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-4762-8738
Ilona Szabłowska-GadomskaLaboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-8649-1503
Anna Nowak-SzwedDepartment of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland.
Stefan RudzińskiLaboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-1122-5796
Maksymilian GofronDepartment of Urology, Municipal Complex Hospital, 42-200 Czestochowa, Poland.ORCID 0009-0007-6738-1150
Przemysław ZygmunciakDepartment of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland.ORCID 0009-0004-1404-7544
Małgorzata Lewandowska-SzumiełLaboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-7140-0541
Wojciech Stanisław ZgliczyńskiDepartment of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland.
Leszek CzupryniakDepartment of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland.
Beata Mrozikiewicz-RakowskaDepartment of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland.ORCID 0000-0002-1160-9204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of diabetic wounds is impaired by the intricate nature of diabetes and its associated complications, necessitating novel strategies. The utilization of mesenchymal stem/stromal cells (MSCs) as a therapeutic modality for chronic and recalcitrant wounds in diabetic patients is an active area of investigation aimed at enhancing its therapeutic potential covering tissue regeneration. The threat posed to the patient and their environment by the presence of a diabetic foot ulcer (DFU) is so significant that any additional therapeutic approach that opens new pathways to halt the progression of local changes, which subsequently lead to a generalized inflammatory process, offers a chance to reduce the risk of amputation or even death. This article explores the potential of MSCs in diabetic foot ulcer treatment, examining their mechanisms of action, clinical application challenges, and future directions for research and therapy.

Indexed as

Diabetic FootMesenchymal Stem CellsMesenchymal Stem Cell TransplantationWound HealingAnimalsHumansallogenic cell therapyATMPcell therapydiabetic foot ulcermesenchymal stem/stromal cells

Identifiers

PMID39596237
PMCPMC11594847

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.