Evidence map›Paper›PMID 39596427›Full record

ArticleInternational journal of molecular sciences2024

Computational Investigation of the Therapeutic Potential of

Jerius Nkwuda Ejeje, Emmanuel Ayodeji Agbebi, Makhosazana Siduduzile Mathenjwa-Goqo, Obinna Aru Oje, Precious Eseose Agboinghale, Ikechukwu Theophilus Ebe, Tajudeen Olabisi Obafemi, Ezekiel Adewole, Omaka N Omaka, Sunday Amos Onikanni and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Uvarinol and Dichamanetin Derived fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. In silico pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jerius Nkwuda EjejePhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.ORCID 0000-0001-8224-9579
Emmanuel Ayodeji AgbebiInstitute of Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.ORCID 0000-0001-9258-3095
Makhosazana Siduduzile Mathenjwa-GoqoBiotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.
Obinna Aru OjeDepartment of Biochemistry, Faculty of Biological Sciences, Alex Ekwueme Federal University Ndufu Alike Ikwo, P.O. Box 1010, Abakaliki 480101, Nigeria.ORCID 0000-0003-0371-2604
Precious Eseose AgboinghalePhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
Ikechukwu Theophilus EbeDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Uburu 491105, Nigeria.ORCID 0009-0000-9545-1389
Tajudeen Olabisi ObafemiPhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
Ezekiel AdewoleDepartment of Chemical Sciences, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
Omaka N OmakaDepartment of Chemistry, Faculty of Physical Sciences, Alex Ekwueme Federal University Ndufu Alike Ikwo, P.O. Box 1010, Abakaliki 480101, Nigeria.
Sunday Amos OnikanniPhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.ORCID 0000-0003-4866-8467
Basiru Olaitan AjiboyePhytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 360101, Nigeria.
Olaposi Idowu OmotuyiInstitute of Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
Babatunji Emmanuel OyinloyePhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.ORCID 0000-0003-2165-7936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) is a multifactorial social problem affecting men worldwide. While phosphodiesterase type 5 inhibitors (PDE5) like sildenafil are commonly used, they often present side effects, underscoring the need for alternative therapies. Therefore, this study investigated the potential of phytochemicals from

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 5Erectile DysfunctionMolecular Docking SimulationCatechinHumansMaleMolecular Dynamics SimulationPhosphodiesterase 5 InhibitorsPhytochemicalsPlant ExtractsSildenafil CitrateCatechinCyclic Nucleotide Phosphodiesterases, Type 5Phosphodiesterase 5 InhibitorsPhytochemicalsPlant ExtractsSildenafil CitratecatechinDetarium senegalenseepicatechinerectile dysfunctionphosphodiesterase 5sildenafil

Identifiers

PMID39596427
PMCPMC11594949

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.