Insights into Medication-Induced Osteonecrosis of the Jaw Through the Application of Salivary Proteomics and Bioinformatics.

Vladimíra Schwartzová, Galina Laputková, Ivan Talian, Miroslav Marcin, Zuzana Schwartzová, Dominik Glaba

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vladimíra SchwartzováClinic of Stomatology and Maxillofacial Surgery, Faculty of Medicine, University of P. J. Šafárik and Louis Pasteur University Hospital, 041 90 Košice, Slovakia.

Galina LaputkováDepartment of Medical and Clinical Biophysics, Faculty of Medicine, University of P. J. Šafárik, 040 11 Košice, Slovakia.ORCID 0000-0001-7152-693X

Ivan TalianDepartment of Medical and Clinical Biophysics, Faculty of Medicine, University of P. J. Šafárik, 040 11 Košice, Slovakia.ORCID 0000-0002-9698-6024

Miroslav MarcinDepartment of Medical and Clinical Biophysics, Faculty of Medicine, University of P. J. Šafárik, 040 11 Košice, Slovakia.ORCID 0000-0002-2306-6411

Zuzana SchwartzováClinic of Stomatology and Maxillofacial Surgery, Faculty of Medicine, University of P. J. Šafárik and Louis Pasteur University Hospital, 041 90 Košice, Slovakia.

Dominik GlabaFaculty of Medicine, University of P. J. Šafárik, 041 90 Košice, Slovakia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term treatment with bisphosphonates is accompanied by an increased risk of medication-related osteonecrosis of the jaw (MRONJ). Currently, no clinically useful biomarkers for the predictive diagnosis of MRONJ are available. To investigate the potential key proteins involved in the pathogenesis of MRONJ, a proteomic LC-MS/MS analysis of saliva was performed. Differentially expressed proteins (DEPs) were analyzed using BiNGO, ClueGO, cytoHubba, MCODE, KEGG, and ReactomeFI software packages using Cytoscape platforms. In total, 1545 DEPs were identified, including 43 up- and 11 down-regulated with a 1.5-fold cut-off value and

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawComputational BiologyProteomicsSalivaAgedBiomarkersFemaleHumansMaleMiddle AgedProtein Interaction MapsTandem Mass SpectrometryBiomarkersbioinformatic analysismedication-related osteonecrosis of the jawproteomicssaliva

Identifiers

PMID39596473

DOI10.3390/ijms252212405

PMCPMC11594355

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.