Evidence map›Paper›PMID 39596527›Full record

ReviewInternational journal of molecular sciences2024

Continuous Use During Disuse: Mechanisms and Effects of Spontaneous Activity of Unloaded Postural Muscle.

Boris S Shenkman, Vitaliy E Kalashnikov, Kristina A Sharlo, Olga V Turtikova, Roman O Bokov, Timur M Mirzoev

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Boris S ShenkmanMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.
Vitaliy E KalashnikovMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.
Kristina A SharloMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.ORCID 0000-0002-5413-6312
Olga V TurtikovaMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.ORCID 0000-0002-7356-219X
Roman O BokovMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.ORCID 0000-0002-4724-8295
Timur M MirzoevMyology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.ORCID 0000-0002-1986-6221

Funding

Russian Science Foundation 22-15-00151
6 · The paper itself

Abstract

In most mammals, postural soleus muscles are involved in the maintenance of the stability of the body in the gravitational field of Earth. It is well established that immediately after a laboratory rat is exposed to conditions of weightlessness (parabolic flight) or simulated microgravity (hindlimb suspension/unloading), a sharp decrease in soleus muscle electrical activity occurs. However, starting from the 3rd day of mechanical unloading, soleus muscle electrical activity begins to increase and reaches baseline levels approximately by the 14th day of hindlimb suspension. This phenomenon, observed in the course of rat hindlimb suspension, was named the "spontaneous electrical activity of postural muscle". The present review discusses spinal mechanisms underlying the development of such spontaneous activity of rat soleus muscle and the effect of this activity on intracellular signaling in rat soleus muscle during mechanical unloading.

Indexed as

Muscle, SkeletalWeightlessnessAnimalsHindlimb SuspensionHumansRatsCLP290intracellular signalingKCC2mechanical unloadingsoleus musclespinal motoneuronsspontaneous activity

Identifiers

PMID39596527
PMCPMC11594575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.