Evidence map›Paper›PMID 39596570›Full record

ArticleGenes2024

Interaction Between PNPLA3 and SIRT5 Genetic Variants in Association with Liver Fibrosis Severity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Kamonchanok Moonlisarn, Pornjira Somnark, Bootsakorn Boonkaew, Chalermarat Bunchorntavakul, Pisit Tangkijvanich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Human PNPLA3FASEB bioAdvances · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kamonchanok MoonlisarnCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Pornjira SomnarkCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Bootsakorn BoonkaewCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Chalermarat BunchorntavakulDivision of Gastroenterology, Department of Medicine, Rajavithi Hospital, Bangkok 10400, Thailand.ORCID 0000-0002-8842-032X
Pisit TangkijvanichCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-2926-8671

Funding

NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (PMU-B) B36G660010
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study evaluated the association between polymorphisms in the

methodsFibrosis and steatosis were assessed by MRE and MRI-PDFF, respectively. The polymorphisms were determined by allelic discrimination in blood samples.

results204 patients aged 57.0 ± 13.5 years were included. Sixty-two (30.4%) patients had significant fibrosis (≥F2). Among F2-F4 fibrosis, the

conclusionsOur data indicate that the

Indexed as

LipaseLiver CirrhosisMembrane ProteinsPolymorphism, Single NucleotideSirtuins17-Hydroxysteroid DehydrogenasesAcyltransferasesAdultAgedFatty LiverFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle Aged17-Hydroxysteroid DehydrogenasesAcyltransferasesHSD17B13 protein, humanLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanSIRT5 protein, humanSirtuinsTM6SF2 protein, humanfibrosisHSD17B13 rs6834314metabolic dysfunction-associated steatotic liver disease (MASLD)PNPLA3 rs738409polymorphismsSIRT5 rs12216101steatosis

Identifiers

PMID39596570
PMCPMC11593416

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.