ArticleGenes2024
Role of LncRNA MSTRG.20890.1 in Hair Follicle Development of Cashmere Goats.
Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Melatonin Regulates the Proliferation of Liaoning Cashmere Goat Skin Fibroblasts via the lncRNA16913.1-chi-miR-195-5p-FZD6 Axis.Animals : an open access journal from MDPI · 2026Article
- Transcriptome analysis reveals the key long non-coding RNAs and genes related to cashmere shedding in goats.Animal bioscience · 2026Article
- Expression dynamics and functional roles of KLF4 during embryonic hair follicle development in cashmere goats.BMC veterinary research · 2026Article
- LncRNA ST6GALNAC3 inhibits dermal fibroblast proliferation and migration in cashmere goat hair follicles via the chi-miR-24-3p/ID4 axis.Animal bioscience · 2025Article
- Whole-transcriptome RNA sequencing reveals global expression dynamics and ceRNA regulatory networks related to hair follicle development and melanogenesis in goats.Animal bioscience · 2025Article
- Role of LncRNA MRPS28 in Secondary Hair Follicle Development of Cashmere Goats.Animals : an open access journal from MDPI · 2025Article
- Identification of lncRNAs involved in the hair follicle cycle transition of cashmere goats in response to photoperiod change.BMC genomics · 2025Article
- LncRNA MSTRG.14227.1 regulates the morphogenesis of secondary hair follicles in Inner Mongolia cashmere goats via targeting ADAMTS3 by sponging chi-miR-433.Journal of animal science · 2025Article
- Whole-genome resequencing to investigate the genetic diversity and the molecular basis underlying key economic traits in indigenous sheep breeds adapted to hypoxic environments.Frontiers in veterinary science · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe cashmere goat is a biological resource that mainly produces cashmere. Cashmere has a soft hand feel and good luster, with high economic value. The quality and yield of cashmere are determined by the process of hair follicle development during the embryonic period.
methodsIn this study, the skin of the Inner Mongolia cashmere goat at different embryonic stages (45, 55, 65, and 75d) was collected, and the differentially expressed lncRNA MSTRG.20890.1 at 75d was obtained by screening. Dual luciferase reporter gene system, qRT-PCR, and EDU experiments were used to verify further the regulatory role and molecular mechanism of the lncRNA in dermal fibroblasts.
resultsBased on the transcriptome database of Inner Mongolia cashmere goat skin at different embryonic stages, which was previously constructed by our group, according to the characteristics of hair follicle development in the embryonic stage, we screened out the lncRNA MSTRG.20890.1 that was down-expressed on the 75-SHFINI day of the embryonic stage. We found that lncRNA MSTRG.20890.1 was mainly located in the cytoplasm of cells, and it could inhibit the proliferation and directional migration of dermal fibroblasts through the chi-miR-24-3p/ADAMTS3 signaling axis, thereby inhibiting the formation of dermal papilla structure at embryonic stage.
conclusionsThis study revealed that lncRNA MSTRG.20890.1 regulated secondary hair follicle morphogenesis and development in cashmere goats through the chi-miR-24-3p/ADAMTS3 signaling axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.