Evidence map›Paper›PMID 39596990›Full record

ArticleMedicina (Kaunas, Lithuania)2024

Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer's Disease: Involvement of TXNIP/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1/HMGB1 Signalling.

Hemat A Elariny, Ahmed M Kabel, Heba Mohammed Refat M Selim, Azza I Helal, Doaa Abdelrahman, Hany M Borg, Mennatallah A Elkady, Lamees M Dawood, Mohamed F El-Badawy, Haifa Faisal A Almalawi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Unraveling the molecular mechanisms of aluminium chloride-induced Alzheimer's disease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Involvement of role of HMGB1-NLRP3 pathway in systemic disorders.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hemat A ElarinyDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 55476, Saudi Arabia.ORCID 0000-0002-0122-4968
Ahmed M KabelPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0002-5101-8011
Heba Mohammed Refat M SelimDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.ORCID 0000-0001-6973-6460
Azza I HelalDepartment of Histology and Cell Biology, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh 33516, Egypt.
Doaa AbdelrahmanInternal Medicine Department, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-4054-2336
Hany M BorgPhysiology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh 33516, Egypt.
Mennatallah A ElkadyPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0002-2063-1606
Lamees M DawoodMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31511, Egypt.
Mohamed F El-BadawyMicrobiology and Immunology Department, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt.ORCID 0000-0002-5896-3067
Haifa Faisal A AlmalawiKing Faisal Medical Complex, Taif Health Cluster, Taif 26513, Saudi Arabia.
El-Shaimaa A ArafaCollege of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates.ORCID 0000-0002-9034-6624
Shuruq E AlsufyaniDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-5567-6169
Hany H ArabDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Funding

Taif University TU-DSPP-2024-116
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aluminum ChlorideAlzheimer DiseaseCanagliflozinNLR Family, Pyrin Domain-Containing 3 ProteinSirtuin 1AnimalsCell Cycle ProteinsDisease Models, AnimalHMGB1 ProteinInflammasomesMaleMitochondriaOxidative StressRatsSignal TransductionAluminum ChlorideCanagliflozinCell Cycle ProteinsHbp1 protein, ratHMGB1 ProteinInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratSirt1 protein, ratSirtuin 1TXNIP protein, rataluminium chlorideAlzheimer’s diseasebehavioural changescanagliflozinratssirtuin-1

Identifiers

PMID39596990
PMCPMC11596744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.